当前位置: X-MOL 学术Immunopharmacol. Immunotoxicol. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Ferulic acid alleviates atopic dermatitis-like symptoms in mice via its potent anti-inflammatory effect.
Immunopharmacology and Immunotoxicology ( IF 3.3 ) Pub Date : 2020-03-03 , DOI: 10.1080/08923973.2020.1733012
Zhike Zhou 1 , Tongxin Shi 1 , Jun Hou 1 , Min Li 1
Affiliation  

Background: Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by the interactions between multiple genetic and environmental factors. The pathogenesis of AD is still not completely clear. Steroid topical therapy has severe side effects for chronic AD symptoms and new therapeutic options are urgently needed. Ferulic acid (FA) is a novel natural dietary polyphenol with anti-oxidative and anti-inflammatory effects.Methods: FA was assessed in BALB/c mice with AD-like lesions resulted from repetitive applications of 2,4-dinitrochlorobenzene (DNCB). Molecular and serological properties of the AD lesions as well as the overall symptomatic score were evaluated.Results: FA ameliorated the overall symptoms of AD, including the severity of skin lesion and incidence of scratching behavior. Systemically, FA markedly decreased DNCB-induced Th2 cytokines and IgE in the peripheral blood. In the local tissue with AD lesions, FA suppressed DNCB-stimulated mRNA production of pro-inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-4, IL-6, and IL-31. In THP-1 cells, a human monocyte model, FA dose-dependently suppressed DNCB-elicited up-regulation of CD54 and CD86 at cell surface, secretion of pro-inflammatory cytokines IL-6 and TNF-α, and NFκB signaling activation.Conclusion: Our findings demonstrated that FA could serve as a promising therapeutic agent in AD treatment.

中文翻译:

阿魏酸通过其有效的抗炎作用缓解小鼠特应性皮炎样症状。

背景:特应性皮炎(AD)是一种慢性炎症性皮肤病,其特征在于多种遗传因素和环境因素之间的相互作用。AD的发病机制仍不完全清楚。类固醇局部治疗对慢性AD症状具有严重的副作用,因此迫切需要新的治疗选择。阿魏酸(FA)是一种新型的天然膳食多酚,具有抗氧化和抗炎作用。方法:在重复施用2,4-二硝基氯苯(DNCB)导致AD样病变的BALB / c小鼠中评估FA。结果:FA改善了AD的总体症状,包括皮肤病变的严重程度和抓挠行为的发生率,从而评估了AD病变的分子和血清学特性以及总体症状评分。系统地 FA显着降低DNCB诱导的外周血Th2细胞因子和IgE。在具有AD病变的局部组织中,FA抑制了DNCB刺激的促炎细胞因子的mRNA产生,例如肿瘤坏死因子(TNF)-α,白介素(IL)-4,IL-6和IL-31。在人类单核细胞模型THP-1细胞中,FA剂量依赖性抑制DNCB引起细胞表面CD54和CD86的上调,促炎性细胞因子IL-6和TNF-α的分泌以及NFκB信号传导的激活。 :我们的发现表明FA可以作为AD治疗中有希望的治疗剂。
更新日期:2020-04-20
down
wechat
bug