A prospective double-blind randomized placebo-controlled study evaluated the tolerance and efficacy of the biological plant-based food supplement Bioticks® (extracts of thyme, rosemary, melissa, fenugreek, absinthe and lemongrass) as a flea-control product. Twelve dogs were used as placebo controls (group A). Ten dogs under similar housing conditions received the same food daily but supplemented with Bioticks® (group B). Flea counts were performed on D0 and 14, then 1, 2, 3, 4 and 5 months after the beginning of the study. No flea treatment was given or environmental modifications made during the 6 months prior to beginning and throughout the duration of the study. Efficacy was calculated according to Abbott's formula. No adverse event was recorded. At inclusion, dogs in groups A and B hosted a mean ± standard deviation of 7.9 ± 3.3 and 9.5 ± 3.6 fleas, respectively. The mean flea population in group A steadily increased until 4 months after D0 (21.5 ± 4.9 fleas/dog). Meanwhile, the mean flea population in group B dogs remained stable for the first month but then steadily decreased to reach an average of 3.1 ± 1.7 fleas/dog at D0+5 months. The percentage efficacy in the treated group as compared to the non-treated group was 33%, 51%, 71%, 80% and 82% at 1, 2, 3, 4 and 5 months, respectively. Bioticks® was shown to be safe and effectively limited the flea population in dogs with a moderate flea infestation in conditions that were highly favourable to flea development. This is the first study to evaluate a plant-based product as an oral supplement for flea control.

中文翻译：

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评估控制犬跳蚤种群的植物性食品补充剂：一项前瞻性双盲随机研究。

一项前瞻性双盲随机安慰剂对照研究评估了以生物植物为基础的食品补充剂Bioticks®（百里香，迷迭香，蜜蜂花，胡芦巴，苦艾酒和柠檬草的提取物）作为跳蚤控制产品的耐受性和功效。十二只狗用作安慰剂对照（A组）。十只狗在相似的住房条件下每天接受相同的食物，但补充了Bioticks®（B组）。在研究开始后的D0和14，然后1、2、3、4和5个月进行跳蚤计数。在研究开始前和整个研究过程中的6个月内未进行跳蚤治疗或进行了环境改良。根据雅培公式计算功效。没有不良事件的记录。纳入时，A和B组的狗的平均±标准偏差为7.9±3.3和9。跳蚤分别为5±3.6。A组的平均跳蚤数量稳定增加，直到D0后4个月（每只狗21.5±4.9只跳蚤）。同时，B组犬的平均跳蚤种群在第一个月保持稳定，但随后在D0 + 5个月稳步下降，平均达到3.1±1.7跳蚤/只狗。与未治疗组相比，治疗组在1、2、3、4和5个月时的功效百分比分别为33％，51％，71％，80％和82％。事实证明，Bioticks®是安全且有效地限制了中度跳蚤侵袭的狗的跳蚤数量，并且条件非常有利于跳蚤的发育。这是第一项评估以植物为基础的产品作为口服蚤补充剂以控制跳蚤的研究。9条跳蚤/狗）。同时，B组犬的平均跳蚤种群在第一个月保持稳定，但随后在D0 + 5个月稳步下降，平均达到3.1±1.7跳蚤/只狗。与未治疗组相比，治疗组在1、2、3、4和5个月时的功效百分比分别为33％，51％，71％，80％和82％。事实证明，Bioticks®是安全且有效地限制了中度跳蚤侵袭的狗的跳蚤数量，并且条件非常有利于跳蚤的发育。这是第一项评估以植物为基础的产品作为口服蚤补充剂以控制跳蚤的研究。9条跳蚤/狗）。同时，B组犬的平均跳蚤种群在第一个月保持稳定，但随后在D0 + 5个月稳步下降，平均达到3.1±1.7跳蚤/只犬。与未治疗组相比，治疗组在1、2、3、4和5个月时的功效百分比分别为33％，51％，71％，80％和82％。事实证明，Bioticks®是安全且有效地限制了中度跳蚤侵袭的狗的跳蚤数量，而条件非常有利于跳蚤的发育。这是第一项评估以植物为基础的产品作为口服蚤补充剂以控制跳蚤的研究。与未治疗组相比，治疗组在1、2、3、4和5个月时的功效百分比分别为33％，51％，71％，80％和82％。事实证明，Bioticks®是安全且有效地限制了中度跳蚤侵袭的狗的跳蚤数量，并且条件非常有利于跳蚤的发育。这是第一项评估以植物为基础的产品作为口服蚤补充剂以控制跳蚤的研究。与未治疗组相比，治疗组在1、2、3、4和5个月时的功效百分比分别为33％，51％，71％，80％和82％。事实证明，Bioticks®是安全且有效地限制了中度跳蚤侵袭的狗的跳蚤数量，并且条件非常有利于跳蚤的发育。这是第一项评估以植物为基础的产品作为口服蚤补充剂以控制跳蚤的研究。