Nipah virus (NiV) is an emerging and priority pathogen from the Paramyxoviridae family with a high fatality rate. It causes various diseases such as respiratory ailments and encephalitis and poses a great threat to humans and livestock. Despite various efforts, there is no approved antiviral treatment available. Therefore, to expedite and assist the research, we have developed an integrative resource NipahVR (http://bioinfo.imtech.res.in/manojk/nipahvr/) for the multi-targeted putative therapeutics and epitopes for NiV. It is structured into different sections, i.e. genomes, codon usage, phylogenomics, molecular diagnostic primers, therapeutics (siRNAs, sgRNAs, miRNAs) and vaccine epitopes (B-cell, CTL, MHC-I and -II binders). Most decisively, potentially efficient therapeutic regimens targeting different NiV proteins and genes were anticipated and projected. We hope this computational resource would be helpful in developing combating strategies against this deadly pathogen. Database URL: http://bioinfo.imtech.res.in/manojk/nipahvr/.

中文翻译：

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NipahVR：尼帕病毒的多靶点假定疗法和表位资源。

尼帕病毒（NiV）是副粘病毒科的一种新兴的优先病原体，具有高致死率。它引起呼吸道疾病、脑炎等多种疾病，对人畜造成巨大威胁。尽管做出了各种努力，但还没有经过批准的抗病毒治疗方法。因此，为了加快和协助研究，我们开发了一个综合资源 NipahVR (http://bioinfo.imtech.res.in/manojk/nipahvr/)，用于 NiV 的多靶点假定疗法和表位。它被构造成不同的部分，即基因组、密码子使用、系统基因组学、分子诊断引物、治疗剂（siRNA、sgRNA、miRNA）和疫苗表位（B 细胞、CTL、MHC-I 和-II 结合物）。最决定性的是，预期并预测了针对不同 NiV 蛋白和基因的潜在有效治疗方案。我们希望这种计算资源有助于制定对抗这种致命病原体的策略。数据库网址：http://bioinfo.imtech.res.in/manojk/nipahvr/。