Clostridioides difficile is the leading cause of hospital-acquired gastrointestinal infections and a major public health burden in the United States. C. difficile infection causes a spectrum of disease from mild diarrhea to severe complications such as pseudomembranous colitis, toxic megacolon and death. This broad range of disease is only partially explained by bacterial genetic factors, host genetics, comorbidities and previous drug exposures. Another important factor is the gut microbiome, the disruption of which results in a loss of colonization resistance to C. difficile. Here, we review how gut microbiota and their metabolites impact C. difficile virulence and influence disease.

中文翻译：

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艰难梭菌感染过程中的微生物-微生物相互作用。

艰难梭菌是美国医院获得性胃肠道感染的主要原因，也是公共卫生的主要负担。艰难梭菌感染会引起一系列疾病，从轻度腹泻到严重的并发症，例如假膜性结肠炎，中毒性巨结肠和死亡。这种广泛的疾病只能通过细菌遗传因素，宿主遗传学，合并症和以前的药物暴露部分解释。另一个重要因素是肠道微生物组，肠道微生物组的破坏导致对艰难梭菌的定植性丧失。在这里，我们审查肠道菌群及其代谢产物如何影响艰难梭菌的毒力并影响疾病。