The field of organic chemistry has recently witnessed a rapid rise in the use of chemoenzymatic strategies for the synthesis of complex molecules. Under this paradigm, biocatalytic methods and contemporary synthetic methods are used synergistically in a multistep approach toward a target molecule. In light of the unparalleled regioselectivity and stereoselectivity of enzymatic transformations and the reaction diversity of contemporary organic chemistry, chemoenzymatic strategies hold enormous potential for streamlining access to important bioactive molecules. This review covers recent demonstrations of chemoenzymatic approaches in chemical synthesis, with special emphasis on the preparation of medicinally relevant natural products.

中文翻译：

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化学活性的生物活性天然产物合成的最新进展。

最近，有机化学领域目睹了使用化学酶策略来合成复杂分子的迅速增长。在这种范式下，生物催化方法和当代合成方法以多步骤的方式协同作用用于目标分子。鉴于酶促转化具有无与伦比的区域选择性和立体选择性以及当代有机化学的反应多样性，化学酶策略在简化对重要生物活性分子的获取方面具有巨大潜力。这篇综述涵盖了化学合成中化学酶学方法的最新论证，特别强调了与医学相关的天然产物的制备。