Poly(ADP-ribose) polymerases (PARPs or ARTDs), originally described as DNA repair factors, have metabolic regulatory roles. PARP1, PARP2, PARP7, PARP10, and PARP14 regulate central and peripheral carbohydrate and lipid metabolism and often channel pathological disruptive metabolic signals. PARP1 and PARP2 are crucial for adipocyte differentiation, including the commitment toward white, brown, or beige adipose tissue lineages, as well as the regulation of lipid accumulation. Through regulating adipocyte function and organismal energy balance, PARPs play a role in obesity and the consequences of obesity. These findings can be translated into humans, as evidenced by studies on identical twins and SNPs affecting PARP activity.

中文翻译：

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ADP-核糖代谢在代谢调节，脂肪组织分化和代谢中的作用。

最初被称为DNA修复因子的聚（ADP-核糖）聚合酶（PARP或ARTD）具有代谢调节作用。PARP1，PARP2，PARP7，PARP10和PARP14调节中枢和外周碳水化合物和脂质代谢，并经常传导病理性破坏性代谢信号。PARP1和PARP2对于脂肪细胞的分化至关重要，包括对白色，棕色或米色脂肪组织谱系的承诺，以及对脂质蓄积的调节。通过调节脂肪细胞功能和机体能量平衡，PARP在肥胖症和肥胖症后果中发挥作用。这些发现可以转化为人类，正如对同卵双胞胎和影响PARP活性的SNP的研究所证明的那样。