Effective maintenance and stability of our genomes is essential for normal cell division, tissue homeostasis, and cellular and organismal fitness. The processes of chromosome replication and segregation require continual surveillance to insure fidelity. Accurate and efficient repair of DNA damage preserves genome integrity, which if lost can lead to multiple diseases, including cancer. Poly(ADP-ribose) a dynamic and reversible posttranslational modification and the enzymes that catalyze it (PARP1, PARP2, tankyrase 1, and tankyrase 2) function to maintain genome stability through diverse mechanisms. Here we review the role of these enzymes and the modification in genome repair, replication, and resolution in human cells.

中文翻译：

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核 PARP 和基因组完整性。

我们基因组的有效维护和稳定性对于正常的细胞分裂、组织稳态以及细胞和有机体健康至关重要。染色体复制和分离的过程需要持续监视以确保保真度。准确有效地修复 DNA 损伤可保持基因组完整性，如果丢失，可能导致多种疾病，包括癌症。聚 (ADP-核糖) 是一种动态且可逆的翻译后修饰，催化它的酶（PARP1、PARP2、tankyrase 1 和 tankyrase 2）通过多种机制发挥维持基因组稳定性的作用。在这里，我们回顾了这些酶的作用以及在人类细胞中基因组修复、复制和分解中的修饰。