Given the critical role that the immune system plays in a multitude of diseases, having a clear understanding of the pharmacology of the immune system is crucial to new drug discovery and development. Here we describe the International Union of Basic and Clinical Pharmacology (IUPHAR) Guide to Immunopharmacology (GtoImmuPdb), which connects expert-curated pharmacology with key immunological concepts and aims to put pharmacological data into the hands of immunologists. In the pursuit of new therapeutics, pharmacological databases are a vital resource to researchers through providing accurate information on the fundamental science underlying drug action. This extension to the existing IUPHAR/British Pharmacological Society Guide to Pharmacology supports research into the development of drugs targeted at modulating immune, inflammatory or infectious components of disease. To provide a deeper context for how the resource can support research we show data in GtoImmuPdb relating to a case study on the targeting of vascular inflammation.

中文翻译：

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IUPHAR 免疫药理学指南：连接免疫学和药理学。

鉴于免疫系统在多种疾病中发挥的关键作用，清楚地了解免疫系统的药理学对于新药的发现和开发至关重要。在这里，我们介绍国际基础与临床药理学联盟 (IUPHAR) 免疫药理学指南 (GtoImmuPdb)，它将专家策划的药理学与关键免疫学概念联系起来，旨在将药理学数据交到免疫学家手中。在寻求新疗法的过程中，药理学数据库通过提供有关药物作用基础科学的准确信息，成为研究人员的重要资源。这一对现有 IUPHAR/英国药理学会药理学指南的扩展支持针对调节疾病的免疫、炎症或感染成分的药物开发研究。为了更深入地了解该资源如何支持研究，我们在 GtoImmuPdb 中展示了与血管炎症靶向案例研究相关的数据。