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Single-cell biomedicine: roles of single-cell nuclear elements.
Cell Biology and Toxicology ( IF 6.1 ) Pub Date : 2020-02-01 , DOI: 10.1007/s10565-020-09515-7
Yiming Zeng 1 , Xiangdong Wang 2 , Jiaqiang Zhang 3
Affiliation  

Single-cell biomedicine, a new merging discipline of cell biology and medicine to improve the life quality of patients, gains high priority in cell biology and toxicology. Single-cell nuclear elements are specially focused and headlined to understand regulatory mechanisms by which transcriptional factors, DNA elements, and genome organization interact with each other and contribute to the developmental evolution and dynamic formation of genotoxicity. Cell molecular phenomics, clonal genotypes, and structural metamorphoses during the cell cycle at single-cell level provide deep insights to understanding mechanism-based bridges between cell biology and toxicology, between cell sensitive and resistance, and between chronic diseases and cancer.

中文翻译:

单细胞生物医学:单细胞核元素的作用。

单细胞生物医学是细胞生物学和医学的新融合学科,旨在提高患者的生活质量,在细胞生物学和毒理学领域具有很高的优先级。单细胞核元件是特别关注和关注的主题,旨在了解调节机制,转录因子,DNA元素和基因组组织通过它们相互相互作用,并有助于遗传毒性的发展演变和动态形成。在单细胞水平的细胞周期中,细胞分子形态学,克隆基因型和结构变态现象为深入理解细胞生物学与毒理学之间,细胞敏感性与耐药性之间以及慢性疾病与癌症之间基于机制的桥梁提供了深刻的见识。
更新日期:2020-02-01
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