Advances in molecular dynamics simulations have led to large increases across spatial and complexity scales, providing valuable molecular level insight into processes occurring on the subcellular level. An increasing repertoire of methods to assemble and analyse complex membrane simulations, alongside advances in structural biology methods for membrane proteins, have contributed to our increased understanding of the roles of specific lipid interactions for multiple membrane protein systems. Large scale simulations of crowded protein solutions have provided a model describing the biophysical basis for experimentally observed diffusion properties. In this review we discuss recent approaches that pave the way towards linking molecular level detail to the cellular level.

中文翻译：

---

模拟亚细胞结构。

分子动力学模拟的进步已导致空间和复杂性规模的大幅增长，从而为分子水平上发生的过程提供了有价值的分子水平见解。越来越多的方法用于组装和分析复杂的膜模拟，以及膜蛋白的结构生物学方法的进步，有助于我们对多种膜蛋白系统中特定脂质相互作用的作用有了更深入的了解。拥挤的蛋白质溶液的大规模模拟提供了一个模型，该模型描述了实验观察到的扩散特性的生物物理基础。在这篇综述中，我们讨论了将分子水平细节与细胞水平联系起来的最新方法。