In demyelinating polyneuropathies, distribution patterns of demyelination reflect underlying pathogenesis. Median and ulnar nerve conduction studies were reviewed in 85 typical chronic inflammatory demyelinating polyneuropathy (CIDP) patients and 29 multifocal acquired demyelinating sensory and motor neuropathy (MADSAM). Distal latencies were prolonged in typical CIDP and near normal in MADSAM. Abnormal amplitude reductions in the nerve trunks were more frequent in MADSAM than typical CIDP. Presumably because the blood-nerve barrier is anatomically deficient at the distal nerve terminals, antibody-mediated demyelination is a major pathophysiology in typical CIDP. In contrast, blood-nerve barrier breakdown is likely to be predominant in MADSAM.

中文翻译：

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慢性炎性脱髓鞘性多发性神经病亚型脱髓鞘的不同分布

在脱髓鞘性多发性神经病中，脱髓鞘的分布模式反映了潜在的发病机制。对 85 名典型慢性炎症性脱髓鞘性多发性神经病 (CIDP) 患者和 29 名多灶性获得性脱髓鞘性感觉和运动神经病 (MADSAM) 患者的正中和尺神经传导研究进行了回顾。典型 CIDP 的远端潜伏期延长，而 MADSAM 则接近正常。MADSAM 中神经干的异常振幅降低比典型的 CIDP 更常见。可能是因为远端神经末梢的血神经屏障在解剖学上有缺陷，抗体介导的脱髓鞘是典型 CIDP 的主要病理生理学。相比之下，血神经屏障破坏可能在 MADSAM 中占主导地位。