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The chemical biology of hydrogen sulfide and related hydropersulfides: interactions with biologically relevant metals and metalloproteins.
Current Opinion in Chemical Biology ( IF 7.8 ) Pub Date : 2020-01-12 , DOI: 10.1016/j.cbpa.2019.11.013
Jon M Fukuto 1 , Valeria Suarez Vega 1 , Carmen Works 1 , Joseph Lin 2
Affiliation  

Hydrogen sulfide and related/derived persulfides (RSnH, RSSnR, n > 1) have been the subject of recent research interest because of their reported physiological signaling roles. In spite of their described actions, the chemical/biochemical mechanisms of activity have not been established. From a chemical perspective, it is likely that metals and metalloproteins are possible biological targets for the actions of these species. Thus, the chemical biology of hydrogen sulfide and persulfides with metals and metalloproteins will be discussed as a prelude to future speculation regarding their physiological function and utility.

中文翻译:

硫化氢和相关氢过硫化物的化学生物学:与生物学相关金属和金属蛋白的相互作用。

硫化氢和相关/衍生的过硫化物(RSnH,RSSNR,n> 1)由于其已报道的生理信号作用而成为近期研究的主题。尽管描述了其作用,但尚未建立活性的化学/生物化学机制。从化学角度看,金属和金属蛋白可能是这些物种作用的生物学目标。因此,将讨论硫化氢和过硫化物与金属和金属蛋白的化学生物学,作为未来推测其生理功能和用途的前奏。
更新日期:2020-01-12
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