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Tissue-specific disruption of the growth hormone receptor (GHR) in mice: An update.
Growth Hormone and IGF Research ( IF 1.4 ) Pub Date : 2019-12-24 , DOI: 10.1016/j.ghir.2019.12.004
Silvana Duran-Ortiz 1 , Vanessa Noboa 2 , John J Kopchick 3
Affiliation  

The Growth hormone receptor (GHR) is expressed in many cells/tissues in the body. To investigate the specific metabolic effects of GH action in distinct tissues, several tissue-specific GHR gene disrupted or knockout (KO) mouse lines have been generated. Previously, we have described the effects of GHRKO in several known insulin sensitive tissues, namely liver, muscle and adipose tissue. In this review, we further explore and summarize the main findings of recently published GHRKO results in liver, adipocytes, intestine, bone, brain and heart.



中文翻译:

小鼠生长激素受体 (GHR) 的组织特异性破坏:更新。

生长激素受体 (GHR) 在体内的许多细胞/组织中都有表达。为了研究不同组织中 GH 作用的特定代谢效应,已经产生了几种组织特异性 GHR 基因破坏或敲除 (KO) 小鼠品系。以前,我们已经描述了 GHRKO 在几种已知的胰岛素敏感组织(即肝脏、肌肉和脂肪组织)中的作用。在这篇综述中,我们进一步探索和总结了最近发表的 GHRKO 在肝脏、脂肪细胞、肠道、骨骼、大脑和心脏中的主要发现。

更新日期:2019-12-24
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