Early detection of Aspergillus infection has the potential to facilitate a more effective management of invasive disease. Data from probable/proven cases of invasive aspergillosis (IA) with a positive galactomannan enzyme-linked immunosorbent assay (GM) bronchoalveolar lavage fluid (BALF) was analyzed in respect to serum GM and/or polymerase chain reaction (PCR) screening of blood samples prior to, or concurrent with bronchoscopy. Concurrent serum GM testing is less sensitive than BALF itself. Nevertheless screening of blood using GM or PCR testing detected IA cases earlier (GM: 42% or PCR: 56%), particularly when combined (GM/PCR: 73%). Therefore, regular screening facilitates and improves early detection of IA in patients suffering from acute leukemia.

中文翻译：

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在IA证实和可能的患者中，通过曲霉菌PCR和半乳甘露聚糖ELISA筛选血液之前进行BAL检测。

曲霉菌感染的早期发现有潜力促进更有效地管理侵袭性疾病。通过半乳甘露聚糖酶联免疫吸附试验（GM）阳性/侵袭性曲霉病（IA）的可能/证实病例的数据，对血清样品的GM和/或聚合酶链反应（PCR）筛查进行了分析在支气管镜检查之前或同时进行。同时进行的血清GM检测不如BALF本身敏感。尽管如此，使用GM或PCR检测筛查血液的时间较早（IA：42％或PCR：56％），尤其是联合使用时（GM / PCR：73％）。因此，定期筛查有助于并改善急性白血病患者中IA的早期检测。