AIMS Most breeds of goat are more susceptible to nematode infection than sheep, and this appears to be a consequence of less effective immune responses. Several papers have considered the effectiveness of eosinophils and immunoglobulin A (IgA) in goats but differences in the induction of responses have not been studied in the same detail. The aim of this study was to look at the induction of eosinophil and IgA responses in Boer goats reared indoors under intensive conditions. METHODS AND RESULTS The goats were experimentally infected with a low dose of 2400 Haemonchus contortus, Trichostrongylus spp. and Oesophagostomum spp. at a 6:1:1 ratio. Faecal egg counts (FEC), packed cell volume (PCV), IgA activity against third-stage larvae and peripheral eosinophilia were measured twice a week for eight weeks. The infection generated an IgA response but did not significantly increase peripheral eosinophilia in the 25 infected kids compared with the 4 control animals. FEC was not associated with IgA activity or eosinophilia. CONCLUSION A detailed analysis of IgA and eosinophil responses to deliberate nematode infection in Boer goats showed that there was an increase in nematode-specific IgA activity but no detectable eosinophil response. In addition, there was no association between increased IgA activity or eosinophilia with egg counts and worm burdens. These suggest that IgA and eosinophils do not act to control nematode infection in goats.

中文翻译：

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低剂量（主要是波尔山羊嗜血曲霉）感染后IgA和嗜酸性粒细胞的动力学。

目的大多数山羊品种比绵羊更容易受到线虫感染，这似乎是有效免疫反应较弱的结果。几篇论文已经考虑了嗜酸性粒细胞和免疫球蛋白A（IgA）在山羊中的有效性，但尚未在同一细节中研究诱导应答的差异。这项研究的目的是研究在密集条件下饲养在室内的波尔山羊中嗜酸性粒细胞和IgA反应的诱导。方法和结果用低剂量的2400捻转血矛线虫Trichostrongylus spp感染山羊。和食管食管菌属。以6：1：1的比例。每周两次，共八周，测量粪便卵数（FEC），堆积细胞体积（PCV），针对第三阶段幼虫的IgA活性和外周嗜酸性粒细胞增多。与4只对照动物相比，感染在25个受感染的孩子中产生了IgA反应，但并未显着增加外周嗜酸性粒细胞增多。FEC与IgA活性或嗜酸性粒细胞增多无关。结论对波尔山羊有意对线虫感染的IgA和嗜酸性粒细胞反应的详细分析表明，线虫特异性IgA活性有所增加，但没有可检测到的嗜酸性粒细胞反应。此外，增加的IgA活性或嗜酸性粒细胞增多与卵数和蠕虫负担之间没有关联。这些表明，IgA和嗜酸性粒细胞不能起到控制山羊线虫感染的作用。结论对波尔山羊有意对线虫感染的IgA和嗜酸性粒细胞反应的详细分析表明，线虫特异性IgA活性有所增加，但没有可检测到的嗜酸性粒细胞反应。此外，增加的IgA活性或嗜酸性粒细胞增多与卵数和蠕虫负担之间没有关联。这些表明，IgA和嗜酸性粒细胞不能起到控制山羊线虫感染的作用。结论对波尔山羊有意对线虫感染的IgA和嗜酸性粒细胞反应的详细分析表明，线虫特异性IgA活性有所增加，但没有可检测到的嗜酸性粒细胞反应。此外，增加的IgA活性或嗜酸性粒细胞增多与卵数和蠕虫负担之间没有关联。这些表明，IgA和嗜酸性粒细胞不能起到控制山羊线虫感染的作用。