Introduction: Cisplatin has been indicated for several malignancies all over the world for many years. Increasing patient tolerance for high dose of chemotherapeutics and reducing side effects has been granted by drug encapsulated liposomal systems. There have been much efforts for improving Cisplatin delivery to the site of action via liposomes both in research and clinical trials such as SPI-077®, Liplacis®, and Lipoplatin®.Areas covered: In this review, we have discussed about Cisplatin and its liposomal formulations, focusing on different preparation methods and analysis approaches such as atomic absorption, mass spectroscopy, UV, electrochemical methods, and emphasizing on HPLC as one of the accurate and specific methods for determination of Cisplatin species and also measurement of total platinum by derivation.Expert Opinion: Liposome of Cisplatin have offered potential beneficial aspects over Cisplatin formulation. However, there are several challenges in preparing and analysis of Cisplatin liposomes due to Cisplatin's great reactivity, formation of several species, high affinity to bio-elements, insufficient release at the tumor site, and inefficient loading. Cisplatin resistance is another challenge which should be prevented by higher loading capacity. Charge dependent interactions should also be highly considered especially in the preparation step.

中文翻译：

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顺铂脂质体制剂的最新进展：制备和分析要点。

简介：多年来，顺铂已在世界范围内用于多种恶性肿瘤的治疗。药物包裹的脂质体系统已允许增加患者对高剂量化疗药物的耐受性并减少副作用。在诸如SPI-077®，Liplacis®和Lipoplatin®之类的研究和临床试验中，人们一直在努力通过脂质体改善顺铂向作用部位的传递。研究领域：在本综述中，我们讨论了关于顺铂及其脂质体制剂，侧重于不同的制备方法和分析方法，例如原子吸收，质谱，UV，电化学方法，并强调HPLC作为测定顺铂物种以及通过衍生法测定总铂金的准确而具体的方法之一。专家意见：顺铂脂质体提供了优于顺铂制剂的潜在有益方面。然而，由于顺铂的高反应性，几种物种的形成，对生物元素的高亲和力，在肿瘤部位的释放不足以及低效的装载，在制备和分析顺铂脂质体方面存在一些挑战。耐顺铂性是另一个挑战，应通过更高的负载量来防止。尤其在制备步骤中，还应高度考虑与电荷有关的相互作用。和低效的加载。耐顺铂性是另一个挑战，应通过更高的负载量来防止。尤其在制备步骤中，还应高度考虑与电荷有关的相互作用。和低效的加载。耐顺铂性是另一个挑战，应通过更高的负载量来防止。尤其在制备步骤中，还应高度考虑与电荷有关的相互作用。