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Genetic structure of the ethnic Lao groups from mainland Southeast Asia revealed by forensic microsatellites
Annals of Human Genetics ( IF 1.9 ) Pub Date : 2020-03-02 , DOI: 10.1111/ahg.12379 Suparat Srithawong 1 , Kanha Muisuk 2 , Metawee Srikummool 3 , Narongdet Mahasirikul 4 , Saksuriya Triyarach 5 , Kamnikone Sriprasert 6 , Wibhu Kutanan 1
Annals of Human Genetics ( IF 1.9 ) Pub Date : 2020-03-02 , DOI: 10.1111/ahg.12379 Suparat Srithawong 1 , Kanha Muisuk 2 , Metawee Srikummool 3 , Narongdet Mahasirikul 4 , Saksuriya Triyarach 5 , Kamnikone Sriprasert 6 , Wibhu Kutanan 1
Affiliation
PURPOSE
Laotians and Lao Isan are widely spread Lao groups who live in Laos and northeastern Thailand, respectively. We explored the genetic structure between them and other ethnic groups from Thailand to clarify historical patterns of admixture between Tai-Kadai and Austroasiatic speakers, and to expand the forensic reference database for the region. SUBJECTS AND METHODS
We combined new genetic data for 554 individuals from 12 populations, typed for 15 autosomal short tandem repeats, with available data from 14 populations from Thailand, for a total of 1,153 raw genotypes belonging to 26 populations. We calculated forensic parameters and performed various analyses on genetic diversity, genetic structure, genetic admixture, and genetic relationships among the studied populations. RESULTS
Forensic estimators suggest a good power of discrimination with the combined power of exclusion ranging from 0.993628 to 0.999991 and a combined power of discrimination value greater than 0.99999999. Generally, the two Laotian groups were genetically similar, but the central Laotians from Vientiane have a closer genetic relationship to the Lao Isan than the northern Laotians from Luang Prabang. The Lao genetic ancestry forms the majority of the Lao Isan genetic makeup, while Austroasiatic ancestry is present at ∼10%-50%. CONCLUSIONS
Lao Isan populations show signs of Lao ancestry and admixture with local Austroasiatic ancestry, which reflect historical migrations from Laos to Thailand. Lao speakers are genetically more homogeneous than Austroasiatic speakers, suggesting differential historical processes.
中文翻译:
法医微卫星揭示东南亚大陆老挝族群的遗传结构
目的老挝人和老挝伊桑人是分布广泛的老挝人群体,分别居住在老挝和泰国东北部。我们探索了他们与来自泰国的其他族群之间的遗传结构,以阐明泰卡代语和南亚语族之间混合的历史模式,并扩展该地区的法医参考数据库。主题和方法 我们将来自 12 个种群的 554 个个体的新遗传数据与来自泰国的 14 个种群的可用数据相结合,分型为 15 个常染色体短串联重复序列,共有 1,153 个原始基因型,属于 26 个种群。我们计算了法医参数并对研究种群之间的遗传多样性、遗传结构、遗传混合和遗传关系进行了各种分析。结果 法医估计器显示出良好的辨别力,综合排除能力范围为 0.993628 至 0.999991,综合辨别力值大于 0.99999999。一般来说,这两个老挝族群的基因相似,但来自万象的中部老挝人与来自琅勃拉邦的北部老挝人相比,与老挝伊桑族的亲缘关系更近。老挝基因血统构成了老挝伊桑基因构成的大部分,而南亚血统约占 10%-50%。结论 老挝伊桑人口显示出老挝血统的迹象,并与当地的南亚血统混合,这反映了从老挝到泰国的历史迁移。说老挝语的人在基因上比说南亚人的人更同质,这表明不同的历史过程。
更新日期:2020-03-02
中文翻译:
法医微卫星揭示东南亚大陆老挝族群的遗传结构
目的老挝人和老挝伊桑人是分布广泛的老挝人群体,分别居住在老挝和泰国东北部。我们探索了他们与来自泰国的其他族群之间的遗传结构,以阐明泰卡代语和南亚语族之间混合的历史模式,并扩展该地区的法医参考数据库。主题和方法 我们将来自 12 个种群的 554 个个体的新遗传数据与来自泰国的 14 个种群的可用数据相结合,分型为 15 个常染色体短串联重复序列,共有 1,153 个原始基因型,属于 26 个种群。我们计算了法医参数并对研究种群之间的遗传多样性、遗传结构、遗传混合和遗传关系进行了各种分析。结果 法医估计器显示出良好的辨别力,综合排除能力范围为 0.993628 至 0.999991,综合辨别力值大于 0.99999999。一般来说,这两个老挝族群的基因相似,但来自万象的中部老挝人与来自琅勃拉邦的北部老挝人相比,与老挝伊桑族的亲缘关系更近。老挝基因血统构成了老挝伊桑基因构成的大部分,而南亚血统约占 10%-50%。结论 老挝伊桑人口显示出老挝血统的迹象,并与当地的南亚血统混合,这反映了从老挝到泰国的历史迁移。说老挝语的人在基因上比说南亚人的人更同质,这表明不同的历史过程。