Malignant pleural mesothelioma (MPM) is a type of cancer characterized by a short survival time and poor prognosis. Malignant pleural mesothelioma is most frequently associated with exposure to asbestos and other elongated mineral fibers. The aim of this study was to examine molecular differences between asbestos-exposed and non-exposed MPM patients and assess prognostic significances of molecular factors. Clinical and genetic data were downloaded from Cancer Genome Atlas. To identify the molecular differences, Significant Analysis of Microarray method was used. Prognostic significances of differentially expressed genes were confirmed by using Kaplan-Meier curve with the Log-Rank test. Although mRNAs did not exhibit any significant differences between the two patient groups, nine miRNAs were found to be down-regulated in the asbestos-exposed group. The top five pathways most relevant to the selected miRNAs were extracted through pathway enrichment analysis. Survival analysis revealed that high expression of only hsa-miR-98 was significantly associated with poor prognosis in patients with asbestos-exposed MPM. Evidence suggests that management of the aggressiveness and progression of asbestos-induced MPM may require high levels of hsa-miR-98 due to its tumor-suppressive role. This study might be helpful in enhancing our understanding of the biological mechanisms underlying asbestos-induced MPM and for acquiring greater insights into targeted therapy.Abbreviations: FDR: false discovery rate; MM: malignant mesothelioma; MPM: malignant pleural mesothelioma; mRNA: messenger RNA; miRNA: microRNA; SAM: significance analysis of microarrays; TCGA: the cancer genome atlas.

中文翻译：

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MicroRNA-98是石棉诱导的间皮瘤的预后因素。

恶性胸膜间皮瘤（MPM）是一种癌症，其特征在于生存时间短且预后不良。恶性胸膜间皮瘤最常与石棉和其他细长矿物纤维接触有关。这项研究的目的是检查接触石棉的MPM患者和未接触石棉的MPM患者之间的分子差异，并评估分子因素的预后意义。临床和遗传数据从癌症基因组图谱下载。为了鉴定分子差异，使用了微阵列显着分析法。差异表达基因的预后意义通过使用Kaplan-Meier曲线与Log-Rank检验进行确认。尽管两个患者组之间的mRNAs没有表现出任何显着差异，但在暴露于石棉的组中发现有九种miRNA被下调。通过途径富集分析提取与所选miRNA最相关的前五个途径。生存分析显示，只有hsa-miR-98的高表达与石棉暴露的MPM患者的不良预后显着相关。有证据表明，由于其抑制肿瘤的作用，管理石棉诱导的MPM的侵略性和进展可能需要高水平的hsa-miR-98。这项研究可能有助于增进我们对石棉诱导的MPM的生物学机制的理解，并有助于获得对靶向治疗的更多见解。MM：恶性间皮瘤；MPM：恶性胸膜间皮瘤；mRNA：信使RNA；miRNA：microRNA；SAM：微阵列的显着性分析；TCGA：癌症基因组图谱。