Doxorubicin (DOX) alone or in combination has been widely used for numerous cancers, including breast, lung, bladder, and so on. In this article, a core/shell/shell structured Fe3O4@SiO2@Au@porous SiO2 particles for the drug delivery and release of DOX was demonstrated, with the aid of near-infrared irradiation. Fe3O4 was used to direct the transportation and delivery of the drug-loaded composite to the target tissues and organs under an external magnetic field, the first layer of SiO2 was used for Au nanoparticle attachment, Au acted as the agent for light-thermal conversion, and the porous SiO2 was used to load DOX. The morphology of the nanoparticles was studied by transmission electron microscopy, and the porous structure was characterized by N2 adsorption/desorption curves. The drug delivery system displayed high drug loading capacity, and the release behavior was largely impacted by the environmental pH. Furthermore, the cytotoxicity of Fe3O4@SiO2@Au@porous SiO2 and DOX loaded Fe3O4@SiO2@Au@porous SiO2 was studied through in vitro 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide cell viability assay.

中文翻译：

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一种新型的Fe3O4 @ SiO2 @ Au @多孔SiO2结构的合成，用于NIR辐射诱导的DOX释放和癌症治疗。

单独或组合使用阿霉素（DOX）已广泛用于许多癌症，包括乳腺癌，肺癌，膀胱癌等。在本文中，通过近红外辐射，证明了核/壳/壳结构的Fe3O4 @ SiO2 @ Au @多孔SiO2颗粒用于DOX的释放和释放。Fe3O4用于在外部磁场下指导载药复合物向目标组织和器官的运输和输送，SiO2的第一层用于金纳米颗粒的附着，Au用作光热转换的试剂，多孔SiO2用于加载DOX。通过透射电子显微镜研究了纳米颗粒的形貌，并通过N 2吸附/解吸曲线表征了多孔结构。药物输送系统显示出高载药量，释放行为很大程度上受环境pH值的影响。此外，通过体外3-（4,5-二甲基噻唑-2-基）-2,5-二苯基四唑溴化电池研究了Fe3O4 @ SiO2 @ Au @多孔SiO2和DOX负载的Fe3O4 @ SiO2 @ Au @多孔SiO2的细胞毒性。生存力测定。