PURPOSE The aim of the study was to exploit the feasibility of thermoluminescent dosimeters (TLDs) in radiation therapy techniques in which high dose per fraction is involved. METHODS Dose-response of TLD-100 (LiF: Mg, Ti) was investigated in both 6-MV photon and 6-MeV electron beams. The element correction factor (ECF) generation method was applied to check the variability of the TLDs response. Two batches of 50 TLDs were divided into groups and exposed in the dose range 0 to 30 Gy. Regression analysis was performed with both linear and quadratic models. For each irradiation beam, the calibration curves were obtained in 3 dose range 0 to 8 Gy, 0 to 10 Gy, and 0 to 30 Gy. The best-fitting model was assessed by the Akaike Information Criterion test. RESULTS The ECF process resulted a useful tool to reduce the coefficients of variation from original values higher than 5% to about 3.5%, for all the batches exposed. The results confirm the linearity of dose-response curve below the dose level of 10 Gy for photon and electron beam and the supralinear trend above. CONCLUSION The TLDs are suitable dosimeters for dose monitoring and verification in radiation treatment involving dose up to 30 Gy in a single fraction.

中文翻译：

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TLD-100 在对大分割放射治疗有用的剂量范围内的剂量反应。

目的 该研究的目的是利用热释光剂量计 (TLD) 在涉及高剂量每部分的放射治疗技术中的可行性。方法 在 6-MV 光子和 6-MeV 电子束中研究 TLD-100 (LiF: Mg, Ti) 的剂量反应。元素校正因子 (ECF) 生成方法用于检查 TLD 响应的可变性。将两批 50 个 TLD 分成几组，在 0 到 30 Gy 的剂量范围内进行照射。使用线性和二次模型进行回归分析。对于每个照射束，在 0 至 8 Gy、0 至 10 Gy 和 0 至 30 Gy 的 3 个剂量范围内获得校准曲线。最佳拟合模型由 Akaike 信息标准测试评估。结果 ECF 过程产生了一个有用的工具，可以将所有暴露批次的变异系数从高于 5% 的原始值降低到大约 3.5%。结果证实了光子和电子束在10 Gy剂量水平以下的剂量-反应曲线的线性以及以上的超线性趋势。结论 TLD 是放射治疗中剂量监测和验证的合适剂量计，单次剂量高达 30 Gy。