In multiple sclerosis (MS), eye movement disorders are common and can be quantified with infrared video-oculography. A well-known abnormality is internuclear ophthalmoplegia (INO). This study aims to describe saccadic abnormalities beyond INO and investigate their clinical relevance. A validated standardized infrared oculography protocol, DEMoNS, was used for quantifying saccadic eye movements in three different tasks in MS patients and healthy controls. The relationship between the saccadic parameters and disease characteristics was investigated. Furthermore, the association between saccadic parameters and visual functioning was analysed using logistic regression models, adjusted for possible confounders. This cross-sectional study included 218 subjects with MS and 58 healthy controls. The latency of all saccades was longer in MS patients than in healthy controls. This saccadic delay was larger in subjects with a longer disease duration and more disabled subjects. Furthermore, it was significantly related to presence of a lower vision-related quality of life. This study provided a comprehensive overview of performance of MS patients in different saccadic tasks, compared to healthy controls. Saccadic delay in MS patients was present in all saccadic tasks and was related to advancing disease and visual functioning in daily life.

中文翻译：

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多发性硬化症的眼跳延迟：定量描述。

在多发性硬化症（MS）中，眼球运动障碍很常见，可以通过红外视频眼动术进行量化。众所周知的异常是核间眼肌麻痹（INO）。这项研究旨在描述INO以外的门畸形，并研究其临床相关性。经过验证的标准化红外眼图协议DEMoNS用于量化MS患者和健康对照者在三个不同任务中的眼跳运动。研究了眼跳参数与疾病特征之间的关系。此外，使用逻辑回归模型分析了视听参数与视觉功能之间的关联，并针对可能的混杂因素进行了调整。这项横断面研究包括218位MS患者和58位健康对照。MS患者的所有扫视潜伏期均长于健康对照者。在疾病持续时间较长且残疾患者较多的受试者中，这种眼跳延迟较大。此外，它与视力低下的生活质量显着相关。这项研究提供了与健康对照组相比，MS患者在不同排球任务中的表现的综合概述。多发性硬化症患者的眼跳延迟存在于所有的眼跳任务中，并且与疾病的恶化和日常生活中的视觉功能有关。这项研究提供了与健康对照组相比，MS患者在不同排球任务中的表现的综合概述。多发性硬化症患者的眼跳延迟存在于所有的眼跳任务中，并且与疾病的恶化和日常生活中的视觉功能有关。这项研究提供了与健康对照组相比，MS患者在不同排球任务中的表现的综合概述。多发性硬化症患者的眼跳延迟存在于所有的眼跳任务中，并且与疾病的恶化和日常生活中的视觉功能有关。