Glutathione S‐transferases omega class 1 (GSTO1‐1) is a unique member of the GST family regulating cellular redox metabolism and innate immunity through the promotion of LPS/TLR4/NLRP3 signalling in macrophages. House dust mite (HDM) triggers asthma by promoting type 2 responses and allergic inflammation via the TLR4 pathway. Although linked to asthma, the role of GSTO1‐1 in facilitating type 2 responses and/or HDM‐driven allergic inflammation is unknown.

中文翻译：

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GSTO1-1 是 M2 巨噬细胞偏斜和 HIF-1α 诱导的嗜酸性粒细胞气道炎症的上游抑制因子

谷胱甘肽 S 转移酶 omega class 1 (GSTO1-1) 是 GST 家族的独特成员，通过促进巨噬细胞中的 LPS/TLR4/NLRP3 信号传导来调节细胞氧化还原代谢和先天免疫。屋尘螨 (HDM) 通过 TLR4 通路促进 2 型反应和过敏性炎症，从而引发哮喘。尽管与哮喘有关，但 GSTO1-1 在促进 2 型反应和/或 HDM 驱动的过敏性炎症中的作用尚不清楚。