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Controlling cell viability and bacterial attachment through fabricating extracellular matrix-like micro/nanostructured surface on titanium implant.
Biomedical Materials ( IF 4 ) Pub Date : 2020-03-02 , DOI: 10.1088/1748-605x/ab70ee
Ping Zhou 1 , Siqi Long , Feifei Mao , Hongxin Huang , Hongjiao Li , Fei He , Rui Zhang , Liling Ren , Jing Chen , Shicheng Wei
Affiliation  

Good osseointegration and gingival epithelial sealing play a key role in preventing peri-implantitis of dental implants. In addition to antibacterial qualities, the transmucosal surface of the implant is beneficial to the growth of fibroblasts and epithelial cells, while its body surface is suitable for the growth of osteoblasts and is resistant to epithelial cells and fibroblasts. In this study, both microgrooves mimicking the extracellular matrix (ECM) and titanium (Ti) dioxide nanotubes with different parameter settings were produced on Ti surfaces. The behavior of MG63 osteoblasts, L929 fibroblasts, SCC epithelial cells and Porphyromonas gingivalis on these decorated Ti surfaces was detected to quantify their performances in terms of osseointegration, biological sealing and antimicrobial ability. Via a scoring method based on these results, we concluded that 100-50-20-10-5 μm width grooves arranged in the horizontal direction at 2 μm depth were the priority for the design of the implant's transmucosal surface. By changing the depth to 3.6 μm and further decorating with 55 nm nanotubes, a best surface design for the implant body was acquired. Hierarchical ECM-like micro/nano patterns could provide novel designs for dental implants to achieve excellent gingival epithelial sealing and osseointegration, which would facilitate the clinical application of dental implants.

中文翻译:

通过在钛植入物上制造细胞外基质样微/纳米结构表面来控制细胞活力和细菌附着。

良好的骨整合和牙龈上皮密封在预防牙种植体的种植体周围炎中起关键作用。除具有抗菌性能外,植入物的粘膜表面还有利于成纤维细胞和上皮细胞的生长,而其体表适合成骨细胞的生长,并且对上皮细胞和成纤维细胞具有抵抗力。在这项研究中,在钛表面上都产生了模仿细胞外基质(ECM)的微沟槽和具有不同参数设置的二氧化钛(Ti)纳米管。检测了MG63成骨细胞,L929成纤维细胞,SCC上皮细胞和牙龈卟啉单胞菌在这些装饰的Ti表面上的行为,以量化其在骨整合,生物密封和抗微生物能力方面的性能。通过基于这些结果的评分方法,我们得出的结论是,在种植体的透粘膜表面设计中优先考虑在水平方向上以2μm的深度排列100-50-20-10-5μm宽度的凹槽。通过将深度更改为3.6μm,并进一步用55 nm纳米管进行装饰,获得了植入物本体的最佳表面设计。类似于ECM的分层微/纳米模式可以为牙科植入物提供新颖的设计,以实现出色的牙龈上皮密封和骨整合,这将有助于牙科植入物的临床应用。
更新日期:2020-03-04
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