Neuroinflammation contributes to the occurrence and development of epilepsy. However, several inflammatory factors that are important for facilitating the diagnosis to reduce or prevent seizures need to be further studied. This study is aimed to explore serum levels of matrix metalloproteinase-9 (MMP-9), interleukin-6 (IL-6), hypersensitive C-reactive protein (hs-CRP), and homocysteine (HCY) in epilepsy patients and the relationship of them with epilepsy. Epilepsy patients (n = 101) in the Second Xiangya Hospital from January 2017 to August 2018 were allocated to the epilepsy groups, which were divided into idiopathic epilepsy group (n = 43) and symptomatic epilepsy group (n = 58) according to the pathogeny. Healthy individuals (n = 50) were allocated to the control group. The concentrations of serum MMP-9, IL-6, hs-CRP, and HCY in all samples were detected by enzyme-linked immunosorbent assay, chemiluminescence method, latex-enhanced immunoturbidimetry, and enzyme circulation method. The levels of serum MMP-9, IL-6, hs-CRP, and HCY in epilepsy patients were higher than those in the control group (P < 0.05, P < 0.01, P < 0.01, and P < 0.01, respectively). The levels of serum MMP-9, IL-6, hs-CRP, and HCY in the symptomatic epilepsy group were higher than those in the control group (P < 0.01 or P < 0.05, respectively). The levels of serum MMP-9, IL-6, and hs-CRP in idiopathic epilepsy patients were higher than those in the control group (P < 0.01 or P < 0.05, respectively). The serum HCY level in the idiopathic epilepsy group was lower than that in the symptomatic epilepsy group (P < 0.01). MMP-9, IL-6, hs-CRP, and HCY may be recommended as the state biomarker to distinguish etiology of epilepsy. We hope our study could provide help in some ways for clinical diagnosis and treatment.

中文翻译：

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癫痫患者血清基质金属蛋白酶9，白介素6，超敏C反应蛋白和同型半胱氨酸水平升高。

神经炎症有助于癫痫的发生和发展。但是，对促进诊断以减少或预防癫痫发作重要的几种炎症因子需要进一步研究。这项研究旨在探讨癫痫患者血清中的基质金属蛋白酶9（MMP-9），白细胞介素6（IL-6），超敏C反应蛋白（hs-CRP）和同型半胱氨酸（HCY）的水平及其关系其中有癫痫病。2017年1月至2018年8月在湘雅市第二医院的癫痫患者（n = 101）分为癫痫组，根据病因分为原发性癫痫组（n = 43）和有症状癫痫组（n = 58）。 。将健康个体（n = 50）分配到对照组。血清MMP-9，IL-6，hs-CRP，通过酶联免疫吸附法，化学发光法，乳胶增强免疫比浊法和酶循环法检测所有样品中的HCY和HCY。癫痫患者的血清MMP-9，IL-6，hs-CRP和HCY水平高于对照组（分别为P <0.05，P <0.01，P <0.01和P <0.01）。有症状癫痫组的血清MMP-9，IL-6，hs-CRP和HCY水平高于对照组（分别为P <0.01或P <0.05）。特发性癫痫患者的血清MMP-9，IL-6和hs-CRP水平高于对照组（分别为P <0.01或P <0.05）。特发性癫痫组的血清HCY水平低于有症状癫痫组（P <0.01）。MMP-9，IL-6，hs-CRP，可能推荐使用HCY和HCY作为区分癫痫病因的状态生物标志物。我们希望我们的研究可以在某些方面为临床诊断和治疗提供帮助。