It is not yet known whether continuous glucose monitoring (CGM) abnormalities persist in young children with CF. We evaluated longitudinal CGM results for children with CF < 10 years of age. We performed 3-day CGM at baseline, 12 months, and 24 months on 11 CF children (1 female) initially aged mean (SD) 3.8 (2.5) years. CGM analysis included (i) mean sensor glucose (SG), (ii) standard deviation (SD) for SG, (iii) peak SG and (iv)% time spent above a threshold of 7.8 mmol/L. Only three (3/11, 27%) had normal CGM at all time-points. Nearly three quarters of the participants (8/11, 73%) spent more than 4.5 percent time > 7.8 mmol/L at one time-point, five of whom had an elevated percent time on a subsequent test. Young children with CF have glucose abnormalities detected by CGM that fluctuate over time.

中文翻译：

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连续血糖监测检测到的血糖异常在患有囊性纤维化的幼儿中很常见

目前尚不清楚连续血糖监测 (CGM) 异常是否持续存在于 CF 幼儿中。我们评估了 CF < 10 岁儿童的纵向 CGM 结果。我们在基线、12 个月和 24 个月时对 11 名初始平均年龄 (SD) 3.8 (2.5) 岁的 CF 儿童（1 名女性）进行了 3 天 CGM。CGM 分析包括 (i) 平均传感器葡萄糖 (SG)、(ii) SG 的标准偏差 (SD)、(iii) 峰值 SG 和 (iv) 超过 7.8 mmol/L 阈值的时间百分比。只有三个 (3/11, 27%) 在所有时间点都具有正常的 CGM。近四分之三的参与者 (8/11, 73%) 在一个时间点花费了超过 4.5% 的时间 > 7.8 mmol/L，其中五人在随后的测试中花费了超过 4.5% 的时间。患有 CF 的幼儿通过 CGM 检测到随时间波动的葡萄糖异常。