The SENTRY Antimicrobial Surveillance Program has monitored bloodstream infections (BSIs) from patients in medical centers worldwide since 1997. In this report, we examine the frequency of occurrence and antimicrobial susceptibility profiles of 6741 bacterial and 222 fungal pathogens causing BSI in 16 medical centers from 2012 to 2017. These results were stratified according to patient age, intensive care unit (ICU) location, and hospital onset (HO) versus community onset (CO) of infection. The leading pathogen isolated from patients in all age groups (range, 20.3-32.5%), except for those >64 years old (19.9%), was Staphylococcus aureus. Escherichia coli was the most common agent in patients over 64 years of age (26.7%). S. aureus was frequently recovered from patients with HO or CO BSI (20.9-24.1%). However, E. coli was the most commonly isolated species (24.5%) from CO infections. BSIs caused by vancomycin-resistant enterococci, penicillin-nonsusceptible S. pneumoniae, extended-spectrum β-lactamase-producing Klebsiella spp., carbapenem-resistant Enterobacteriaceae, and multidrug-resistant Pseudomonas aeruginosa were more common among patients in ICUs compared to patients hospitalized in a non-ICU setting. The frequency of methicillin-resistant S. aureus (MRSA) was slightly higher in the non-ICU population (37.5%) compared with the ICU group (34.1%). A trend toward a decrease in BSIs due to Gram-positive cocci and an increase in infections with Gram-negative bacilli were observed. Overall, the frequency of resistant phenotypes was high for S. aureus (MRSA; 37.0%), enterococci (vancomycin-resistant enterococci; 24.6%), Klebsiella spp. (extended-spectrum β-lactamase phenotype; 21.5%), and P. aeruginosa (multidrug-resistant; 15.4%) and generally declined from 2012 to 2017, whereas the frequency of penicillin-nonsusceptible Streptococcus pneumoniae (3.4%) and carbapenem-resistant Enterobacteriaceae (1.5%) was low overall and both resistant phenotypes declined over time. Fluconazole-resistant Candida spp. isolates were only detected in years 2013-2015.

中文翻译：

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从血流感染患者中分离出的细菌和真菌病原体：SENTRY抗菌素监测计划（2012-2017）的发生频率和抗菌素敏感性模式。

自1997年以来，SENTRY抗菌素监测计划已监测了全球医疗中心患者的血流感染（BSI）。在本报告中，我们研究了自2012年以来在16个医疗中心中引起BSI的6741种细菌和222种真菌病原体的发生频率和抗菌药性概况至2017年。根据患者年龄，重症监护病房（ICU）位置以及医院感染（HO）与社区感染（CO）的不同，对这些结果进行了分层。从所有年龄组（范围为20.3-32.5％）的患者中分离出的主要病原体是金黄色葡萄球菌，但年龄大于64岁的（19.9％）除外。大肠杆菌是64岁以上患者中最常见的药物（26.7％）。金黄色葡萄球菌经常从HO或CO BSI患者中恢复（20.9-24.1％）。但是，E。大肠杆菌是从CO感染中最常见的分离物种（24.5％）。与ICU患者相比，ICU患者中因万古霉素耐药的肠球菌，对青霉素不敏感的肺炎链球菌，产生广谱β-内酰胺酶的克雷伯菌属，对碳青霉烯耐药的肠杆菌科细菌和对多药耐药的铜绿假单胞菌引起的BSI较住院患者更为常见。非ICU设置。与ICU组（34.1％）相比，非ICU人群（37.5％）的耐甲氧西林金黄色葡萄球菌（MRSA）频率稍高。观察到由于革兰氏阳性球菌引起的BSI减少和革兰氏阴性杆菌感染增加的趋势。总体而言，金黄色葡萄球菌（MRSA； 37.0％），肠球菌（耐万古霉素的肠球菌； 24.6％），克雷伯菌属的耐药表型频率较高。（广谱β-内酰胺酶表型； 21.5％）和铜绿假单胞菌（多药耐药； 15.4％），从2012年到2017年总体下降，而对青霉素不敏感的肺炎链球菌的发生频率（3.4％）和对碳青霉烯耐药肠杆菌科（1.5％）总体较低，两种耐药表型均随时间下降。耐氟康唑的念珠菌属。仅在2013-2015年检测到分离株。