当前位置: X-MOL 学术Scand. J. Immunol. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
The prostaglandin E2 increases the production of IL-17 and the expression of costimulatory molecules on γδ T cells in rheumatoid arthritis.
Scandinavian Journal of Immunology ( IF 3.7 ) Pub Date : 2020-02-28 , DOI: 10.1111/sji.12872
Boyu Du 1, 2 , Min Zhu 1 , Youling Li 3 , Gang Li 3 , Xueyan Xi 1, 3, 4
Affiliation  

γδ T cells play important roles in the development of rheumatoid arthritis (RA) through their antigen-presenting capacity, release of pro-inflammatory cytokines, immunomodulatory properties, interaction with CD4+ CD25+ Tregs and promotion of antibody production by helping B cells. Although prostaglandin E2 (PGE2) was proved to have the ability to enhance the antigen-presenting function of dendritic cells and IL-17 production of CD4+ αβ T cells in RA, the role of PGE2 in γδ T cells from RA disease has not yet been clarified. The goal of this study was to determine the role of PGE2 in γδ T cells in RA. We first demonstrated that the population of γδT17 cells increased in patients with RA compared to healthy controls. Then, IL-17A level in patients with RA was shown to increase compared to healthy controls. After adding PGE2 to γδ T cells from patients with RA, the IL-17A level increased accordingly, and the expression of the costimulatory molecules, CD80 and CD86, on these cells also increased. These results suggest that PEG2 can increase the production of IL-17A and the expression of CD80 and CD86 on γδ T cells in patients with RA. These findings will benefit to explore new therapeutic targets for RA disease.

中文翻译:

类风湿关节炎中,前列腺素E2可增加IL-17的产生以及γδT细胞上共刺激分子的表达。

γδT细胞通过其抗原呈递能力,促炎性细胞因子的释放,免疫调节特性,与CD4 + CD25 + Treg的相互作用以及通过帮助B细胞促进抗体生成而在类风湿性关节炎(RA)的发展中发挥重要作用。尽管已证明前列腺素E2(PGE2)具有增强RA中树突状细胞的抗原呈递功能和IL-17产生CD4 +αβT细胞的能力,但尚未发现PGE2在RA疾病的γδT细胞中的作用澄清。这项研究的目的是确定PGE2在RA的γδT细胞中的作用。我们首先证明,与健康对照组相比,RA患者的γδT17细胞数量增加。然后,与健康对照组相比,RA患者的IL-17A水平升高。将PGE2添加到RA患者的γδT细胞中后,IL-17A水平相应增加,并且这些细胞上的共刺激分子CD80和CD86的表达也增加。这些结果表明,PEG2可以增加RA患者γδT细胞中IL-17A的产生以及CD80和CD86的表达。这些发现将有助于探索RA疾病的新治疗靶标。
更新日期:2020-02-28
down
wechat
bug