Background: 

The purpose of the study was to examine 5-year changes in eyes with optic disc drusen at baseline on optical coherence tomography (OCT) scans and the relation of incident drusen to hyperreflective prelaminar lines.

Methods: 

The study included children who presented at baseline, when participants were aged 11–12 years, and again 5 years later. Grading for optic disc drusen was made in all. Grading for prelaminar lines was made in all children at follow-up and in eyes with optic disc drusen at baseline. Analyses included associations with scleral canal diameter at baseline in all children with optic disc drusen and a nested control group of 115 children without optic disc drusen. Data are reported as the number of children having at least one drusen or at least one hyperreflective line per person.

Results: 

The analysis included 724 children who attended both rounds of the study. Of these, 11 (1.5%) had optic disc drusen at baseline. Five additional children had developed optic disc drusen at follow-up, whereas optic disc drusen had disappeared in none, so that 16 (2.2%) children had optic disc drusen in one or both eyes at follow-up. Children with optic disc drusen at the 5-year follow-up had had a mean scleral canal diameter of 1,364 µm (interquartile range [IQR] 81 µm), compared with 1,457 µm (IQR 197) µm in 115 nested controls without optic disc drusen (P < 0.001). Optic disc drusen at follow-up were associated with more hypermetropic refraction. All children who had optic disc drusen at follow-up also had prelaminar hyperreflective lines. In addition, such lines were found at follow-up in 24 of the remaining 708 children without optic disc drusen (P < 0.001). Prelaminar hyperreflective lines with or without optic disc drusen were associated with a narrower scleral canal (diameter 1,364 µm, IQR 119 µm) compared with absence of prelaminar lines (1,486 µm, IQR 206 µm; P < 0.0001).

Conclusion: 

This study provides the first evidence from a prospective study that small optic discs and prelaminar hyperreflective lines on OCT are risk factors for the development of optic disc drusen. The association between prelaminar hyperreflective lines, hypermetropia, and a narrow scleral canal supports that a crowded disc is an essential predisposing factor for the development of optic disc drusen.

中文翻译：

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在哥本哈根儿童研究小组2000年眼研究中，椎板前高反射线在5年内发展为视盘玻璃疣。

背景： 

这项研究的目的是在光学相干断层扫描（OCT）扫描中检查基线时视盘玻璃疣在眼睛中的5年变化，以及玻璃疣入射与超反射前椎板线的关系。

方法： 

该研究包括基线时出现的儿童，参与者年龄在11-12岁之间，五年后再次出现。视盘玻璃膜疣的分级已全部完成。随访时对所有患儿及基线视盘性玻璃疣患者进行分层。分析包括所有患有视神经玻璃疣的患儿与基线时巩膜管直径的相关性，以及115名无视神经玻璃疣的患儿的对照组。数据报告为每人拥有至少一条玻璃疣或至少一条高反射线的儿童人数。

结果： 

分析包括724名儿童，他们参加了两轮研究。在这些患者中，有11名（1.5％）在基线时有视盘玻璃疣。另有五名儿童在随访中发展为视盘玻璃疣，而视神经玻璃疣未见消失，因此有16名（2.2％）儿童在随访中一只或两只眼睛患有视盘玻璃疣。在5年的随访中，患有视盘玻璃疣的儿童的巩膜平均直径为1,364 µm（四分位间距[IQR] 81 µm），相比之下，在115例无视盘玻璃疣的嵌套对照中，儿童的巩膜平均直径为1,457 µm（IQR 197）。 （P<0.001）。随访时视盘玻璃膜疣与远视屈光度更高有关。所有在随访中患有视盘玻璃膜疣的儿童也有椎板前高反射线。此外，在随访的其余708名无视盘玻璃膜疣的儿童中，有24条发现了这种线（P <0.001）。与没有前椎板线（1,486 µm，IQR 206 µm；P <0.0001）相比，有或没有视盘玻璃膜疣的层前高反射线与巩膜管狭窄（直径1,364 µm，IQR 119 µm ）相关。

结论： 

这项研究提供了一项前瞻性研究的第一个证据，即OCT上的小视盘和椎板前高反射线是视盘玻璃疣发展的危险因素。层间高反射线，远视和狭窄的巩膜管之间的联系支持椎间盘突出是视盘玻璃疣发展的重要诱因。