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Interstitial diffuse optical probe with spectral fitting to measure dynamic tumor hypoxia
Biomedical Physics & Engineering Express Pub Date : 2020-01-30 , DOI: 10.1088/2057-1976/ab6e16
Leonard Che Fru 1 , Steven L Jacques 2 , Kwang P Nickel 3, 4 , Tomy Varghese 1, 5 , Michael W Kissick 1 , Larry A DeWerd 1, 6 , Randall J Kimple 3, 4
Affiliation  

Understanding the dynamic nature of tumor hypoxia is vital for cancer therapy. The presence of oxygen within a tumor during radiation therapy increases the likelihood of local control. We used a novel interstitial diffuse optical probe to make real-time measurements of blood volume fraction and hemoglobin oxygen saturation within a tumor at a high temporal resolution. This device was initially characterized and benchmarked using a customized vessel designed to control hemoglobin oxygen saturation and blood volume in a solution of blood with different concentrations of an oxygen scavenger, tetrakis (hydroxymethyl) phosphonium chloride. The optical device was found to consistently monitor the changes in oxygen saturation and these changes correlated to the concentration of the oxygen scavenger added. In near-simultaneous measurements of blood volume and oxygen saturation in tumor-bearing mice, the changes in blood volume fraction and oxygen saturation measured with the interstitial diffuse optical probe were benchmarked against photoacoustic imaging system to track and compare temporal dynamics of oxygen saturation and blood volume in a patient-derived xenograft model of hypopharyngeal carcinoma. Positive correlations between our device and photoacoustic imaging in measuring blood volume and oxygen saturation were observed.

中文翻译:

具有光谱拟合的间质漫反射光学探头测量动态肿瘤缺氧

了解肿瘤缺氧的动态性质对于癌症治疗至关重要。放射治疗期间肿瘤内氧气的存在增加了局部控制的可能性。我们使用新型间质漫反射光学探头以高时间分辨率实时测量肿瘤内的血液体积分数和血红蛋白氧饱和度。该装置最初使用定制的容器进行表征和基准测试,该容器旨在控制具有不同浓度除氧剂四(羟甲基)氯化鏻的血液溶液中的血红蛋白氧饱和度和血容量。发现该光学装置能够持续监测氧饱和度的变化,这些变化与添加的除氧剂浓度相关。在近乎同时测量荷瘤小鼠的血容量和血氧饱和度时,用间质漫射光学探头测量的血容量分数和血氧饱和度的变化与光声成像系统进行了对比,以跟踪和比较血氧饱和度和血氧饱和度的时间动态患者来源的下咽癌异种移植模型中的体积。观察到我们的设备和光声成像在测量血容量和氧饱和度方面存在正相关。用间质扩散光学探头测量的血容量分数和血氧饱和度的变化与光声成像系统进行了基准测试,以跟踪和比较患者来源的下咽癌异种移植模型中血氧饱和度和血容量的时间动态。观察到我们的设备和光声成像在测量血容量和氧饱和度方面存在正相关。用间质扩散光学探头测量的血容量分数和血氧饱和度的变化与光声成像系统进行了基准测试,以跟踪和比较患者来源的下咽癌异种移植模型中血氧饱和度和血容量的时间动态。观察到我们的设备和光声成像在测量血容量和氧饱和度方面存在正相关。
更新日期:2020-01-30
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