The M50 and M100 auditory evoked responses reflect early auditory processes in the primary/secondary auditory cortex. Although previous M50 and M100 studies have been conducted on individuals with autism spectrum disorder (ASD) and indicate disruption of encoding simple sensory information, analogous investigations of the neural correlates of auditory processing through development from children into adults are very limited. Magnetoencephalography was used to record signals arising from the left and right superior temporal gyrus during auditory presentation of tones to children/adolescents and adults with ASD as well as typically developing (TD) controls. One hundred and thirty-two participants (aged 6–42 years) were included into the final analyses (children/adolescents: TD, n = 36, 9.21 ± 1.6 years; ASD, n = 58, 10.07 ± 2.38 years; adults: TD, n = 19, 26.97 ± 1.29 years; ASD, n = 19, 23.80 ± 6.26 years). There were main effects of group on M50 and M100 latency (p #x3c; 0.001) over hemisphere and frequency. Delayed M50 and M100 latencies were found in participants with ASD compared to the TD group, and earlier M50 and M100 latencies were associated with increased age. Furthermore, there was a statistically significant association between language ability and both M50 and M100 latencies. Importantly, differences in M50 and M100 latencies between TD and ASD cohorts, often reported in children, persisted into adulthood, with no evidence supporting latency convergence.
Dev Neurosci 2019;41:223–233

中文翻译：

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整个生命周期中自闭症谱系障碍的延迟听觉诱发反应。

M50和M100听觉诱发反应反映了初级/次级听觉皮层中的早期听觉过程。尽管先前的M50和M100研究已经针对自闭症谱系障碍（ASD）的个体进行，并且表明编码简单的感觉信息受到干扰，但是对于从儿童到成人发育的听觉处理神经相关性的类似研究非常有限。磁脑描记术用于记录听觉向患有ASD的儿童/青少年和成人以及典型的发育（TD）控件发出声音时左右左右颞上回产生的信号。132名参与者（6-42岁）被纳入最终分析（儿童/青少年：TD，n = 36，9.21±1.6岁； ASD，n = 58，10.07±2.38年; 成人：TD，n = 19，26.97±1.29岁; ASD，n = 19，23.80±6.26岁）。小组对半球和频率上的M50和M100潜伏期（p＃x3c； 0.001）有主要影响。与TD组相比，ASD参与者的M50和M100潜伏期延迟，而M50和M100的较早潜伏期与年龄增加有关。此外，在语言能力与M50和M100潜伏期之间存在统计学上的显着关联。重要的是，经常在儿童中报告的TD和ASD队列之间的M50和M100潜伏期差异一直持续到成年，没有证据支持潜伏期收敛。
Dev Neurosci 2019; 41：223–233