High-mobility group box 1 (HMGB1) can act as a structural protein of the chromatin and at the same time as a mediator of the immune system. Its high correlation with the graft acceptance in pancreatic islet recipients makes it a biomarker in islet transplantation. With the suspicion that preexisting HMGB1 in the fetal bovine serum (FBS) would be detrimental to the viability and function of murine beta cells, HMGB1 was removed from FBS and its impact was investigated. Interestingly, the elimination of HMGB1 from FBS seemed unfavorable to the viability and function of cultured murine beta cells, suggesting that the preexisting HMGB1 in the FBS may be an indispensable component of islet cell culture.

中文翻译：

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胎牛血清中已存在的HMGB1对小鼠胰腺β细胞生物学的影响。

高迁移率族盒1（HMGB1）可以充当染色质的结构蛋白，并同时充当免疫系统的介质。它与胰岛受体接受移植物的高度相关性使其成为胰岛移植的生物标志物。怀疑胎牛血清（FBS）中预先存在的HMGB1会对鼠β细胞的生存力和功能有害，因此从FBS中删除了HMGB1，并对其影响进行了研究。有趣的是，从FBS中清除HMGB1似乎不利于培养的鼠β细胞的生存能力和功能，这表明FBS中预先存在的HMGB1可能是胰岛细胞培养中不可缺少的组成部分。