Cadmium is involved in female gonadal toxicity. Although many studies concur in suggesting a significant influence on female reproduction, the mechanisms of action are still needed to study. This study was designed to examine the characteristics of 0, 5, 10, and 20 μM cadmium toxicity in granulosa cells culture for 12 h, and the subsequent effect of cadmium exposure on AMH production and formation. Here we demonstrate that the viability of granulosa cells cadmium exposed was decreased, and the apoptosis was increased. Intriguingly, After exposure to cadmium the SCF was decreased and the AMH was increased in granulosa cells. This study may demonstrate that AMH signaling is involved in Cd action through SCF activation. The signaling pathways may play a role in the reproductive effects caused by environmental and occupational exposures to Cd. These results further confirm the functional significance of AMH signaling in mediating the intraovarian actions of Cd.

中文翻译：

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抗苗勒管激素通过负调控干细胞因子而参与由于镉暴露引起的卵巢颗粒细胞损伤。

镉与女性性腺毒性有关。尽管许多研究都认为对女性生殖有重要影响，但仍需要研究其作用机理。本研究旨在检查颗粒细胞培养12小时后0、5、10和20μM镉的毒性特征，以及镉暴露对AMH生成和形成的后续影响。在这里，我们证明暴露的颗粒细胞镉的生存能力降低，并且细胞凋亡增加。有趣的是，暴露于镉后，颗粒细胞中的SCF降低且AMH升高。这项研究可能证明AMH信号通过SCF激活参与了Cd的作用。信号通路可能在环境和职业暴露于Cd引起的生殖效应中起作用。