Vascular access to tumour tissue limits oxygenation, but also availability to nutrition and penetration of drugs. The development of an increased interstitial fluid pressure in the tumour may obstruct the perfusion capacity of the fragile capillaries, thereby preventing the antitumoral drugs from reaching the target. The haphazard vascular network in tumours seems to become gradually better organized following antiangiogenic treatments, but, new approaches for a facilitated drug transport into the tumour tissue should be investigated.

中文翻译：

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抗分泌因子AF-16改善了进入大鼠乳腺肿瘤的血管通路。

血管进入肿瘤组织限制了氧合作用，但也限制了营养和药物的渗透。肿瘤中组织液压力的升高可能会阻碍脆弱的毛细血管的灌注能力，从而阻止抗肿瘤药物到达靶标。经过抗血管生成治疗后，肿瘤中的随机性血管网络似乎逐渐变得井井有条，但是，应研究促进药物向肿瘤组织中转移的新方法。