The greater amberjack Seriola dumerili is a new aquaculture fish that may display reproductive dysfunctions. During extensive follicular atresia, which is a common reproductive dysfunction in females during vitellogenesis, part of the reabsorbed yolk returns to the liver to be metabolized and recycled. Melanomacrophage centres (MMCs) are aggregates of macrophage-like cells that play a role in the destruction, detoxification and recycling of endogenous and exogenous materials, and have been associated with systemic stress. Wild and captive-reared greater amberjack were sampled in the Mediterranean Sea during two different phases of the reproductive cycle. The liver of reproductively dysfunctional captive-reared females sampled during the spawning season showed a high density of both MMCs and apoptotic cells. A weak liver anti-cytochrome P450 monooxygenase 1A immunoreactivity was observed, suggesting that the examined fish were not exposed to environmental pollutants. We propose that the observed increase in MMCs and apoptosis in captive-reared fish was related to the hepatic overload associated to the metabolism of yolk proteins reabsorbed during extensive follicular atresia. Since follicular atresia is a frequent physiological and pathological event in teleosts, we suggest that the reproductive state should be always assessed when MMCs are used as markers of exposure to stress or pollutants.

中文翻译：

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繁殖功能障碍的雌性a鱼Seriola dumerili的肝脏中黑色素巨噬细胞中心增加（Risso，1810年）。

较大的mber鱼Seriola dumerili是一种可能表现出生殖功能障碍的新型水产养殖鱼。在卵泡形成闭锁过程中，卵泡闭锁是女性的常见生殖功能障碍，部分重吸收的卵黄返回肝脏进行代谢和再循环。黑色素巨噬细胞中心（MMCs）是巨噬细胞样细胞的聚集体，它们在破坏，解毒和再循环内源性和外源性物质中发挥作用，并与系统性应激相关。在繁殖周期的两个不同阶段，在地中海采样了野生的和圈养的大mber。在产卵季节采集的繁殖功能不佳的圈养雌性动物的肝脏显示出高密度的MMC和凋亡细胞。观察到较弱的肝脏抗细胞色素P450单加氧酶1A免疫反应性，表明所检查的鱼没有暴露于环境污染物中。我们建议，观察到的圈养养鱼中MMCs和细胞凋亡的增加与广泛卵泡闭锁期间重吸收的蛋黄蛋白代谢相关的肝脏超负荷有关。由于卵泡闭锁是硬骨鱼中常见的生理和病理事件，因此我们建议，当MMCs用作暴露于压力或污染物的标志物时，应始终评估生殖状态。我们建议，观察到的圈养养鱼中MMCs和细胞凋亡的增加与广泛卵泡闭锁期间重吸收的蛋黄蛋白代谢相关的肝脏超负荷有关。由于卵泡闭锁是硬骨鱼中常见的生理和病理事件，因此我们建议，当MMCs用作暴露于压力或污染物的标志物时，应始终评估生殖状态。我们建议，观察到的圈养养鱼中MMCs和细胞凋亡的增加与广泛卵泡闭锁期间重吸收的蛋黄蛋白代谢相关的肝脏超负荷有关。由于卵泡闭锁是硬骨鱼中常见的生理和病理事件，因此我们建议，当MMCs用作暴露于压力或污染物的标志物时，应始终评估生殖状态。