The novel coronavirus (2019-nCoV) infection caused pneumonia. we retrospectively analyzed the virus presence in the pharyngeal swab, blood, and the anal swab detected by real-time PCR in the clinical lab. Unexpectedly, the 2109-nCoV RNA was readily detected in the blood (6 of 57 patients) and the anal swabs (11 of 28 patients). Importantly, all of the 6 patients with detectable viral RNA in the blood cohort progressed to severe symptom stage, indicating a strong correlation of serum viral RNA with the disease severity (p-value = 0.0001). Meanwhile, 8 of the 11 patients with annal swab virus-positive was in severe clinical stage. However, the concentration of viral RNA in the anal swab (Ct value = 24 + 39) was higher than in the blood (Ct value = 34 + 39) from patient 2, suggesting that the virus might replicate in the digestive tract. Altogether, our results confirmed the presence of virus RNA in extra-pulmonary sites.

中文翻译：

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血液中可检测的2019-nCoV病毒RNA是进一步临床严重程度的有力指标。

新型冠状病毒（2019-nCoV）感染引起肺炎。我们回顾性分析了在临床实验室中通过实时PCR检测到的咽拭子，血液和肛门拭子中的病毒存在情况。出乎意料的是，在血液（57名患者中的6名）和肛门拭子（28名患者中的11名）中很容易检测到2109-nCoV RNA。重要的是，血液队列中所有6例可检测到病毒RNA的患者均进展为严重症状期，表明血清病毒RNA与疾病严重程度密切相关（p值= 0.0001）。同时，在11名肛门拭子病毒阳性患者中，有8名处于严重临床阶段。然而，来自患者2的肛门拭子中的病毒RNA浓度（Ct值= 24 + 39）高于血液（Ct值= 34 + 39），这表明该病毒可能在消化道中复制。共，