The Transient Receptor Potential Melastatin 8 (TRPM8) ion channel is an important sensor of environmental cold temperatures. Cold- and menthol-induced activation of this channel requires the presence of the membrane phospholipid phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2]. This review discusses recent findings on the role of PI(4,5)P2 and G-proteins in the modulation of TRPM8 upon receptor activation. We will also summarize knowledge on the role of PI(4,5)P2 in Ca2+ dependent desensitization/adaptation of TRPM8 activity, and recent advances in the structural basis of how this lipid binds to TRPM8.

中文翻译：

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磷酸肌醇和Gq偶联受体对冷敏TRPM8通道的调节。

瞬态受体潜在的Melastatin 8（TRPM8）离子通道是环境低温的重要传感器。冷和薄荷醇诱导的该通道的激活需要存在膜磷脂磷脂酰肌醇4,5-双磷酸[PI（4,5）P2]。这篇综述讨论了PI（4,5）P2和G蛋白在受体激活后调节TRPM8中的作用的最新发现。我们还将总结关于PI（4,5）P2在依赖Ca2 +的脱敏/适应性TRPM8活性中的作用的知识，以及该脂质如何与TRPM8结合的结构基础的最新进展。