Developmental neuronal remodeling shapes the mature connectivity of the nervous system in both vertebrates and invertebrates. Remodeling often combines degenerative and regenerative events, and defects in its normal progression have been linked to neurological disorders. Here we review recent progress that highlights the roles of cell-cell interactions during remodeling. We propose that these are fundamental to elucidating how spatiotemporal control of remodeling and coordinated circuit remodeling are achieved. We cover examples spanning various neuronal circuits in vertebrates and invertebrates and involving interactions between neurons and different cell types.

中文翻译：

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在我朋友的帮助下：细胞间通讯如何影响神经元重塑。

发育神经元重塑塑造了脊椎动物和无脊椎动物中神经系统的成熟连通性。重塑通常将退化和再生事件结合在一起，其正常进程中的缺陷与神经系统疾病有关。在这里，我们回顾了最近的进展，该进展突出了重塑过程中细胞间相互作用的作用。我们认为，这些对于阐明如何实现时空控制的重塑和协调电路重塑是至关重要的。我们涵盖了跨越脊椎动物和无脊椎动物的各种神经元回路，并涉及神经元与不同细胞类型之间相互作用的例子。