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RP-HPLC and UV Spectrophotometric Analysis of Paracetamol, Ibuprofen, and Caffeine in Solid Pharmaceutical Dosage Forms by Derivative, Fourier, and Wavelet Transforms: A Comparison Study.
Journal of Analytical Methods in Chemistry ( IF 2.6 ) Pub Date : 2020-02-08 , DOI: 10.1155/2020/8107571
Hoang Vu Dang 1 , Huong Truong Thi Thu 1 , Ly Dong Thi Ha 1 , Huong Nguyen Mai 1
Affiliation  

Different signal-transforming algorithms were applied for UV spectrophotometric analysis of paracetamol, ibuprofen, and caffeine in ternary mixtures. Phosphate buffer pH 7.2 was used as the spectrophotometric solvent. Severe overlapping spectra could be resolved into individual bands in the range of wavelengths 200–300 nm by using Savitzky–Golay smoothing and differentiation, trigonometric Fourier series, and mother wavelet functions (i.e., sym6, haar, coif3, and mexh). To optimize spectral recoveries, the concentration of various types of divisors (single, double, and successive) was tested. The developed spectrophotometric methods showed linearity over the ranges 20–40 mg/L for paracetamol, 12–32 mg/L for ibuprofen, and 1–3.5 mg/L for caffeine (R2 > 0.990). They could be successfully applied to the assay and dissolution test of paracetamol, ibuprofen, and caffeine in their combined tablets and capsules, with accuracy (99.1–101.5% recovery) and precision (RSD , suggesting possible interchange between UV spectrophotometric and HPLC methods for routine analysis of paracetamol, ibuprofen, and caffeine in their solid pharmaceutical dosage forms.

中文翻译:

RP-HPLC和UV分光光度法通过衍生,傅立叶和小波变换分析固体药物剂型中的扑热息痛,布洛芬和咖啡因:比较研究。

将不同的信号转换算法用于三元混合物中扑热息痛,布洛芬和咖啡因的紫外分光光度分析。pH 7.2磷酸盐缓冲液用作分光光度法溶剂。通过使用Savitzky-Golay平滑和微分,三角傅里叶级数和母小波函数(即sym6,haar,coif3和mexh),可以将严重的重叠光谱分解为200-300 nm波长范围内的各个波段。为了优化光谱回收率,测试了各种类型的除数(单,双和连续)的浓度。发达的分光光度法显示对乙酰氨基酚的线性范围为20–40 mg / L,布洛芬为12–32 mg / L,咖啡因为1-3.5 mg / L(R2> 0.990)。它们可以成功地用于扑热息痛的分析和溶出度测试,
更新日期:2020-02-08
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