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Cancer-Related Anemia Is a Risk Factor for Medium-Term Postoperative Cognitive Dysfunction in Laparoscopic Surgery Patients: An Observational Prospective Study.
Neural Plasticity ( IF 3.1 ) Pub Date : 2020-02-06 , DOI: 10.1155/2020/4847520
Huimei Huang 1, 2 , Fei Lin 1, 2 , Liming Cen 1, 2 , Ren Jing 1, 2 , Linghui Pan 1, 2
Affiliation  

Anemia in the elderly may impair cognitive function. Our primary objective was to determine whether cancer-related anemia was associated with postoperative cognitive dysfunction (POCD) in nonelderly patients. We conducted an observational prospective study of 177 patients scheduled for laparoscopic surgery. Patients aged 18-64 were divided into two groups according to whether they were anemic due to cancer or not. The cognitive function was assessed by the Mini-Mental State Examination (MMSE) 1 day before and 1 week after operation. The cognitive function of the patients was evaluated by using the Telephone Interview for Cognitive Status-Modified (TICS-M) 3 months after operation. The quality of life of patients was evaluated after operation. The hemoglobin level and other clinical data were recorded before operation. Of the 170 patients, 100 without anemia and 70 anemia patients had been evaluated 1 week after operation. POCD was detected in 43 cases (25.3% of 170 cases) at 1 week and 30 cases (19% of 158 cases) at 3 months postoperatively. Anemia was an independent risk factor for 3-month POCD occurrence (). The education level of the patients who had POCD at 1 week and 3 months after operation was lower (, , respectively). Age was independently associated with the incidence of POCD at 3 months (). In general, these findings suggested that anemia may increase the incidence of medium-term POCD in cancer patients undergoing laparoscopic surgery.

中文翻译:

癌症相关的贫血是腹腔镜手术患者中期术后认知功能障碍的危险因素:一项观察性前瞻性研究。

老年人贫血可能损害认知功能。我们的主要目的是确定非老年患者的癌症相关性贫血是否与术后认知功能障碍(POCD)有关。我们对计划进行腹腔镜手术的177例患者进行了一项观察性前瞻性研究。根据他们是否因癌症而贫血,将18-64岁的患者分为两组。术前1天和术后1周通过迷你精神状态检查(MMSE)评估认知功能。术后3个月,通过电话访问认知状态改变(TICS-M)来评估患者的认知功能。术后评估患者的生活质量。术前记录血红蛋白水平及其他临床资料。在170名患者中,术后1周评估了100例无贫血和70例贫血患者。术后1个月检出POCD 43例(占​​170例的25.3%),术后3个月检出30例(占158例的19%)。贫血是3个月POCD发生的独立危险因素()。术后1周和3个月接受POCD的患者的教育水平较低( 分别地)。年龄与3个月时POCD的发生率独立相关()。通常,这些发现表明,贫血可能会增加接受腹腔镜手术的癌症患者中期POCD的发生率。
更新日期:2020-02-06
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