BACKGROUND Brugada syndrome (BrS) is sometimes diagnosed because of chest pain. Prevalence and characteristics of such BrS patients are unknown. METHODS A total of 200 BrS probands were retrospectively included. BrS diagnosis made because of chest pain (n = 34, 17%) was compared to the other ones. RESULTS BrS probands with diagnosis because of chest pain had significantly more often smoker habits, increased body mass index, and familial history of coronary artery disease but less frequently previous resuscitated sudden death/syncope or atrial fibrillation. Presence of coronary spasm and familial coronary artery disease were independently associated with BrS diagnosed because of chest pain. They presented more often with spontaneous type 1 ST elevation (59% vs 26%, P = .0004) and higher ST elevation during the episode of chest pain compared to other patients or compared to baseline electrocardiogram after chest pain resumption. ST elevation during chest pain was lower compared to ajmaline test. A total of 20% of them had significant coronary artery disease and four (11%) had coronary spasm, and they experienced more often recurrent chest pain episodes (24% vs 5%, P = .0002). Presence of chest pain at BrS diagnosis was not correlated to future arrhythmic events in univariate analysis. Only previous sudden cardiac death (SD)/syncope and familial SD were still significantly associated with outcome in multivariate analysis. CONCLUSION Chest pain is a common cause for BrS diagnosis, although major part is not apparently explained by ischemic heart disease. Mechanisms leading to chest main remain unknown in the other ones. ST elevation is higher in this situation but does not seem to carry poor prognosis.

中文翻译：

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Brugada综合征的胸痛：患病率，相关性和预后作用。

背景技术有时由于胸痛而诊断出Brugada综合征（BrS）。此类BrS患者的患病率和特征尚不清楚。方法回顾性地包括200个BrS先证者。将因胸痛而做出的BrS诊断与其他诊断相比较（n = 34，17％）。结果由于胸痛而被诊断为BrS的先证者有更多的吸烟习惯，体重指数增加和家族性冠状动脉疾病史，但先前复苏的猝死/晕厥或心房颤动的发生率却较低。冠心痉挛和家族性冠状动脉疾病的存在与由于胸痛而诊断出的BrS独立相关。他们出现自发性1型ST抬高的频率更高（59％比26％，P =。与其他患者或恢复胸痛后的基线心电图相比，在胸痛发作期间0004和更高的ST升高。与阿玛琳测试相比，胸痛期间的ST升高较低。共有20％的人患有严重的冠状动脉疾病，四名（11％）患有冠状动脉痉挛，并且他们经历了更频繁的反复胸痛发作（24％vs 5％，P = .0002）。在单因素分析中，BrS诊断时胸痛的存在与将来的心律失常事件无关。在多变量分析中，仅先前的猝死（SD）/晕厥和家族性SD仍然与预后显着相关。结论胸痛是BrS诊断的常见原因，尽管缺血性心脏病显然不能解释其主要部分。导致胸主干的机制在其他机制中仍然未知。在这种情况下ST抬高较高，但预后似乎不佳。