Olfactory receptors (ORs) are a group of G protein coupled receptors (GPCRs) that initiate chemical odorant signals. Although ORs are predominantly located in nasal epithelia to detect smell, these receptors are also present in peripherally in non-nasal organs/tissues. Since the quality of life and cognitive and sensorial features of sense of smell are worsened in multiple chemical sensitivity due to the interaction of ORs with offending compounds, it is important to not only differentiate these receptors from other GPCRs but also characterize these organelles to understand the underlying mechanisms of smelling disorders. The aim of this study was develop computerized programs to differentiate ORs from GPCRs. The computer program was developed on the basis of widely accepted basic algorithms. It is noteworthy that an accuracy of 95.5% was attained, a level not achieved using other established techniques for screening of ORs from GPCRs. The high accuracy rate indicates that this method of differential identification appears reliable. Our findings indicate that this novel method may be considered as a tool for identification and characterization of receptors which might aid in therapeutic approaches to human chemical-mediated sensitization.

中文翻译：

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G蛋白偶联受体的计算机筛选，以鉴定和表征嗅觉受体。

嗅觉受体（OR）是一组G蛋白偶联受体（GPCR），它们会引发化学气味信号。尽管ORs主要位于鼻上皮中以检测气味，但这些受体也存在于非鼻器官/组织的外围。由于ORs与有害化合物的相互作用，在多种化学敏感性中生活质量以及嗅觉的认知和感官特征会恶化，因此，重要的是不仅要区分这些受体与其他GPCR，而且还要表征这些细胞器以了解嗅觉障碍的潜在机制。这项研究的目的是开发计算机程序以区分OR与GPCR。该计算机程序是在广泛接受的基本算法的基础上开发的。值得注意的是，准确率达到了95.5％，使用其他既有技术从GPCR中筛选OR所无法达到的水平。较高的准确率表明这种差分识别方法显得可靠。我们的发现表明，这种新颖的方法可以被认为是鉴定和表征受体的工具，这可能有助于人类化学介导的致敏治疗方法。