Objective: Previously we observed an attenuation of body temperature in lactating rats treated with lipopolysaccharide (LPS) compared with virgin saline-treated females. We proposed that high levels of prolactin (PRL) during lactation may induce this attenuation because PRL has a suppressive effect on inflammation. In the present study, we induced hyperprolactinemia in female virgin rats to investigate the effects of PRL on body temperature and sickness behavior induced by LPS. Methods: To induce hyperprolactinemia, female rats in the estrous phase received domperidone 3 times/day for 5 days and an LPS injection (D + LPS group). Two other groups were treated with saline solution for 5 days, and one of them received a saline injection (S + S group) and the other LPS (S + LPS group). Tympanic temperature was assessed 0, 2, 4, 6, 8, 10, 24, 48, 72, and 96 h after treatment. Body weight gain and food and water consumption were observed 24, 48, 72, and 96 h after treatment. Results: Hyperprolactinemia impaired LPS-induced hypothermia and hyperthermia phases of body temperature. Body weight gains in the S + LPS group and the D + LPS group were similar. A decrease in food consumption was observed in the D + LPS rats at 72 and 96 h compared to the S + LPS group. Conclusion: Hyperprolactinemia impaired the body temperature increase induced by LPS and several signs of sickness behavior, suggesting that febrile responses to LPS can be modulated by the physiological state. These phenomena may have adaptive value for reproduction.
Neuroimmunomodulation 2019;26:285–291

中文翻译：

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高泌乳素血症损害脂多糖对处女雌性大鼠体温和疾病行为的影响。

目的：以前我们观察到与未经生理盐水处理的雌性动物相比，接受脂多糖（LPS）治疗的泌乳大鼠的体温降低。我们提出，泌乳过程中高水平的催乳激素（PRL）可能会导致这种衰减，因为PRL对炎症具有抑制作用。在本研究中，我们诱导了雌性处女大鼠的高泌乳素血症，以研究PRL对LPS诱导的体温和疾病行为的影响。方法：为了诱发高泌乳素血症，处于发情期的雌性大鼠每天接受3次多潘立酮治疗，共5天，并注射LPS（D + LPS组）。另外两个组用盐溶液治疗5天，其中一个组接受盐水注射（S + S组），另一个接受LPS（S + LPS组）。治疗后0、2、4、6、8、10、24、48、72和96小时评估鼓膜温度。治疗后24、48、72和96小时观察到体重增加以及食物和水的消耗。结果：高泌乳素血症会损害LPS诱导的体温过低和体温过高。S + LPS组和D + LPS组的体重增加相似。与S + LPS组相比，D + LPS大鼠在72和96 h时食物消耗减少。结论：高泌乳素血症会损害LPS引起的体温升高和一些疾病行为的迹象，这表明对LPS的发热反应可以通过生理状态进行调节。这些现象可能具有复制的适应性价值。
神经免疫调节2019; 26：285–291