Introduction: The plant, Astilboides tabularis (Hemsl.) Engler, is used in Chinese and Korean medicine to regulate blood sugar levels; however, little is known about its precise effects.

Materials and Methods: In this study, we aimed to measure the composition as well as the antioxidant, and anti-proliferative capacities of A. tabularis. Various extracts were generated using different organic solvents, and in vitro antioxidant activities were evaluated using DPPH free radical-scavenging and reducing power assays. The extracts were also evaluated based on their ability to inhibit lipopolysaccharide (LPS)-induced Nitric Oxide (NO) production in RAW 264.7 cells.

Results: Research shows that the A. tabularis ethyl acetate (EtOAc) extract showed significant antioxidant activity. Additionally, this extract could inhibit the LPS-induced expression of inflammatory mediators and pro-inflammatory cytokines in RAW 264.7 cells, including inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and interleukin-1 beta (IL-1ß). Notably, the A. tabularis EtOAc extract also displayed potent cytotoxic effects against MCF-7 and HeLa cancer cell lines, as determined by MTT assays. Lastly, total phenol and flavonoid content was measured for all extracts, and four flavonoid compounds-catechin, kaempferol, quercitrin, and isoquercetin were isolated from the EtOAc extract. Their structures were confirmed using mass spectrometry and nuclear magnetic resonance, and these isolated compounds were found to display potent DPPH free radical-scavenging activity.

Conclusion: Thus, our data suggest that phenolic compounds in A. tabularis extracts promote antioxidant activity, and furthermore, these extracts show numerous features that indicate potential for therapeutic development.

简介：该植物名为Astilboides tabularis（Hemsl。）Engler，用于中，韩医学中以调节血糖水平。但是，对其精确效果知之甚少。

材料和方法：在这项研究中，我们旨在测量烟曲霉的成分以及抗氧化和抗增殖能力。使用不同的有机溶剂生成各种提取物，并使用DPPH自由基清除和还原能力测定法评估体外抗氧化活性。还根据提取物在RAW 264.7细胞中抑制脂多糖（LPS）诱导的一氧化氮（NO）生成的能力进行评估。

结果：研究表明，板状曲霉乙酸乙酯（EtOAc）提取物显示出显着的抗氧化活性。此外，该提取物还可以抑制LPS诱导的RAW 264.7细胞中炎症介质和促炎细胞因子的表达，包括诱导型一氧化氮合酶（iNOS），环氧合酶2（COX-2）和白介素1β（IL- 1ß）。值得注意的是，如通过MTT测定法所确定的那样，平板农杆菌的EtOAc提取物还显示出对MCF-7和HeLa癌细胞系的有效细胞毒性作用。最后，测量所有提取物的总酚和类黄酮含量，并从EtOAc提取物中分离出四种类黄酮化合物-儿茶素，山奈酚，槲皮素和异槲皮素。通过质谱和核磁共振证实了它们的结构，

结论：因此，我们的数据表明油松提取物中的酚类化合物具有增强抗氧化活性的作用，此外，这些提取物还具有许多特征，表明其具有治疗潜力。