Chronic obstructive pulmonary disease (COPD) is the third leading cause of mortality worldwide. The chronic progressive disease is accompanied by a high loss of health-related quality of life (HRQoL). The available drugs only have symptomatic effects; therefore, non-pharmacological therapies are essential.Areas covered:This systematic review examines non-pharmacological interventions consisting of pulmonary rehabilitation, physical activity, and training versus usual care or no intervention in COPD using at least one of the following HRQoL measuring instruments: St. George's Respiratory Questionnaire, Clinical COPD Questionnaire, COPD Assessment Test, and EuroQol-5D. Of 1532 identified records from CENTRAL, MEDLINE, and EMBASE, 15 randomized controlled trials met the inclusion criteria. Pulmonary rehabilitation programs were investigated in nine studies, education and counselling-based training programs in three studies, and breathing exercises in three studies. Ten studies were found that investigated non-pharmacological treatment programs that led to a significant and clinically relevant improvement in HRQoL compared with usual care or no treatment.Expert Opinion:Non-pharmacological interventions consisting of pulmonary rehabilitation, education and counselling-based training programs, and breathing exercises can improve the HRQoL of COPD patients.

中文翻译：

---

非药物COPD管理对健康相关生活质量的有效性-系统评价。

慢性阻塞性肺疾病（COPD）是全球第三大死亡原因。慢性进行性疾病伴随着与健康有关的生活质量（HRQoL）的高度丧失。现有药物仅具有症状作用。因此，非药物治疗是必不可少的。涵盖的领域：本系统综述使用以下HRQoL测量仪器中的至少一种检查非药物干预，包括肺康复，体力活动，训练与常规护理或无COPD干预。乔治的呼吸问卷，COPD临床问卷，COPD评估测试和EuroQol-5D。在来自CENTRAL，MEDLINE和EMBASE的1532个已确定记录中，有15个随机对照试验符合纳入标准。在九项研究中调查了肺康复计划，在三项研究中调查了基于教育和咨询的培训计划，并在三项研究中调查了呼吸练习。十项研究发现，与非常规治疗相比，非药物治疗计划导致了HRQoL的显着改善和临床相关性改善。专家意见：由肺康复，教育和咨询为基础的培训计划组成的非药物干预措施，呼吸运动可以改善COPD患者的HRQoL。