Autoantibodies play an important role in the destruction of non-infected red blood cells (nRBCs) during malaria. However, the relationship between this clearance and ABO blood groups is yet to be fully enlightened, especially for Plasmodium vivax infections. Here we show that anti-RBC IgG and IgM are increased in anemic patients with acute vivax malaria. Furthermore, both antibodies are able to decrease the deformability of nRBCs, but only IgG can induce in vitro erythrophagocytosis. Such effects are enhanced in type O erythrocytes, suggesting that individuals from this blood group infected with P. vivax malaria may be more susceptible to develop anemia.

自身抗体在疟疾中对未感染的红细胞（nRBC）的破坏中起重要作用。但是，这种清除率与ABO血型之间的关系尚待充分阐明，尤其是对于间日疟原虫感染。在这里，我们显示抗RBC IgG和IgM在患有急性间日疟的贫血患者中增加。此外，两种抗体都能够降低nRBC的可变形性，但是只有IgG可以诱导体外红细胞吞噬。这种作用在O型红细胞中得到增强，表明来自该血型的感染间日疟原虫的个体可能更容易发生贫血。