RNA-binding proteins (RBPs) play important roles in regulating the expression of genes involved in human physiological and pathological processes, especially in cancers. Many RBPs have been found to be dysregulated in cancers; however, there was no tool to incorporate high-throughput data from different dimensions to systematically identify cancer-related RBPs and to explore their causes of abnormality and their potential functions. Therefore, we developed a database named RBPTD to identify cancer-related RBPs in humans and systematically explore their functions and abnormalities by integrating different types of data, including gene expression profiles, prognosis data and DNA copy number variation (CNV), among 28 cancers. We found a total of 454 significantly differentially expressed RBPs, 1970 RBPs with significant prognostic value, and 53 dysregulated RBPs correlated with CNV abnormality. Functions of 26 cancer-related RBPs were explored by analysing high-throughput RNA sequencing data obtained by crosslinking immunoprecipitation, and the remaining RBP functions were predicted by calculating their correlation coefficient with other genes. Finally, we developed the RBPTD for users to explore functions and abnormalities of cancer-related RBPs to improve our understanding of their roles in tumorigenesis. Database URL: http: //www.rbptd.com.

中文翻译：

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RBPTD：人类中与癌症相关的RNA结合蛋白的数据库。

RNA结合蛋白（RBP）在调节与人类生理和病理过程有关的基因表达中起着重要作用，尤其是在癌症中。已发现许多RBP在癌症中失调。但是，没有工具可以整合来自不同维度的高通量数据来系统地识别与癌症相关的RBP，并探讨其异常原因及其潜在功能。因此，我们开发了一个名为RBPTD的数据库，以鉴定人类中与癌症相关的RBP，并通过整合28种癌症中不同类型的数据（包括基因表达谱，预后数据和DNA拷贝数变异（CNV））来系统地探索其功能和异常。我们发现总共454个差异表达明显的RBP，1970个具有明显预后价值的RBP，53例RBP失调与CNV异常有关。通过分析通过交联免疫沉淀获得的高通量RNA测序数据来探索26种与癌症相关的RBP的功能，并通过计算它们与其他基因的相关系数来预测剩余的RBP功能。最后，我们为用户开发了RBPTD，以探索与癌症相关的RBP的功能和异常，以增进我们对其在肿瘤发生中的作用的了解。数据库URL：http：//www.rbptd.com。我们为用户开发了RBPTD，以探索与癌症相关的RBP的功能和异常，以加深我们对其在肿瘤发生中的作用的了解。数据库URL：http：//www.rbptd.com。我们为用户开发了RBPTD，以探索与癌症相关的RBP的功能和异常，以加深我们对其在肿瘤发生中的作用的了解。数据库URL：http：//www.rbptd.com。