Sleep duration may be associated with risk of osteoporosis, with suggestions that too little or indeed too much sleep may be detrimental to bone health. In this study, we considered whether perceived sleep quality is also associated with bone health in older adults. We explored this association in a cohort of 443 older community-dwelling UK adults. Sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI); poor sleep quality was defined as > 5 on this score system. Bone density, shape and microarchitecture were assessed using dual energy X-ray absorptiometry (DXA), peripheral quantitative computed tomography (pQCT) and high-resolution pQCT (HRpQCT). Thirty-seven percent of men and 43% of women had a PSQI score greater than 5, indicative of poor perceived sleep. We found that quality of sleep was associated with altered bone microarchitecture. In men, poor sleep quality was associated with lower radial trabecular (4% slice, p < 0.04) and cortical (66% slice, p = 0.02) bone mineral density, as well as decreased tibial cortical density (p < 0.02) and increased porosity (p < 0.04), but increased size of the tibia (p < 0.04). In women, poor perceived sleep quality was associated with thinner (p < 0.03) and less dense (p < 0.04) cortices of the radius, but greater tibial trabecular number (p < 0.02) and lower separation (p < 0.04). Relationships with DXA parameters were non-significant after adjustment for confounders. Taking sleep medications was associated with decreased tibial size (38% and 66% slices) and strength in women (all p < 0.05), but not in men. Perceived sleep quality was associated with altered bone density and microarchitecture in older adults, and these differences varied according to biological sex and site. Further work is indicated to investigate possible mechanisms underlying these observations.

中文翻译：

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自我报告的老年人睡眠质量和骨结局：赫特福德郡队列研究的结果。

睡眠时间可能与骨质疏松症的风险有关，建议睡眠时间过少或确实过多会损害骨骼健康。在这项研究中，我们考虑了老年人的睡眠质量是否也与骨骼健康有关。我们在443个居住在社区中的英国成年人中进行了探讨。使用匹兹堡睡眠质量指数（PSQI）评估睡眠质量；在该评分系统上，睡眠质量差被定义为> 5。使用双能X射线吸收法（DXA），外周定量计算机断层扫描（pQCT）和高分辨率pQCT（HRpQCT）评估骨密度，形状和微结构。37％的男性和43％的女性的PSQI得分大于5，表明睡眠不足。我们发现睡眠质量与骨微结构的改变有关。在男性中，睡眠质量差与radial骨小梁（4％切片，p <0.04）和皮质（66％切片，p = 0.02）的骨矿物质密度降低以及胫骨皮质密度降低（p <0.02）和升高有关。孔隙率（p <0.04），但胫骨的大小增加（p <0.04）。在女性中，较差的睡眠质量与with骨皮质变薄（p <0.03）和密度较小（p <0.04），胫骨小梁数目较大（p <0.02）和分离度较低（p <0.04）有关。调整混杂因素后，与DXA参数的关系不显着。服用睡眠药物与女性胫骨大小减少（38％和66％切片）和强度降低有关（所有p <0.05），而男性则没有。觉察到的睡眠质量与老年人骨密度和微结构的改变有关，并且这些差异根据生物学性别和部位而变化。指出需要进一步的工作来调查这些观察结果的潜在机制。