Apathy is a central predictor of a poor functional outcome in schizophrenia. Schizophrenia polygenic risk scores (PRSs) are used to detect genetic associations to key clinical phenotypes in schizophrenia. We explored the associations between schizophrenia PRS and apathy levels in schizophrenia spectrum disorders (n = 281) and matched healthy controls (n = 298), and further how schizophrenia PRS contributed in predicting apathy when added to premorbid and clinical factors in the patient sample.

中文翻译：

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精神分裂症谱系障碍和健康对照中精神分裂症多基因风险与冷漠之间的关联

冷漠是精神分裂症不良功能结果的主要预测因素。精神分裂症多基因风险评分 (PRS) 用于检测与精神分裂症关键临床表型的遗传关联。我们探讨了精神分裂症 PRS 与精神分裂症谱系障碍（n = 281）和匹配的健康对照（n = 298）中的冷漠水平之间的关联，并进一步探讨了当将精神分裂症 PRS 添加到患者样本中的病前和临床因素时，如何有助于预测冷漠。