In an aging society, the number of people suffering from Alzheimer's Disease (AD) is still growing. Currently, intensive research is being carried out on the pathogenesis of AD. The results of these studies indicated that oxidative stress plays an important role in the onset and development of this disease. Moreover, in AD oxidative stress is generated by both genetic and biochemical factors as well as the functioning of the systems responsible for their formation and removal. The genetic factors associated with the regulation of the redox system include TOMM40, APOE, LPR, MAPT, APP, PSEN1 and PSEN2 genes. The most important biochemical parameters related to the formation of oxidative species in AD are p53, Homocysteine (Hcy) and a number of others. The formation of Reactive Oxygen Species (ROS) is also related to the efficiency of the DNA repair system, the effectiveness of the apoptosis, autophagy and mitophagy processes as well as the antioxidant potential. However, these factors are responsible for the development of many disorders, often with similar clinical symptoms, especially in the early stages of the disease. The discovery of markers of the early diagnosis of AD may contribute to the introduction of pharmacotherapy and slow down the progression of this disease.

在老龄化社会中，罹患阿尔茨海默氏病（AD）的人数仍在增长。当前，正在对AD的发病机理进行深入研究。这些研究的结果表明，氧化应激在该疾病的发作和发展中起重要作用。此外，在AD中，遗传和生化因素以及负责其形成和去除的系统的功能均产生氧化应激。与氧化还原系统的调节相关的遗传因素包括TOMM40，APOE，LPR，MAPT，APP，PSEN1和PSEN2基因。与AD中氧化性物质形成有关的最重要的生化参数是p53，同型半胱氨酸（Hcy）等。活性氧（ROS）的形成还与DNA修复系统的效率，细胞凋亡，自噬和线粒体吞噬过程的有效性以及抗氧化剂的潜力有关。然而，这些因素导致许多疾病的发展，这些疾病通常具有相似的临床症状，尤其是在疾病的早期阶段。AD早期诊断的标志物的发现可能有助于药物治疗的引入，并减缓该疾病的进展。