A follow-up study evaluated the chemical and physical parameters of 10 disposable nitrile glove products in association with the observed variability in chemical permeation performance. The aim was to determine which polymer properties explained or were predictive of the observed wide variation in breakthrough time and steady state permeation rate. The physical and mechanical properties evaluated were thickness, area density, volume fraction and modulus 50-100%. The chemical composition properties evaluated were relative acrylonitrile content, relative carboxylation content, oily plasticizers, inorganic fillers and organic polymer content. A combination of correlation and multiple regression analyses were performed to evaluate the predictive nature of these parameters. For the regression analyses, stepwise, forward selection and backward elimination methods were used to determine an optimal regression fit. Both thickness and area density were strongly correlated with the breakthrough time. With the addition of volume fraction, these factors accounted for about 88-89% of the variation in breakthrough times. The correlation results for the steady-state permeation rate were largely inconclusive and only a moderate correlation with thickness was observed with one solvent. However, regression analyses revealed a moderate to strong association (R2 = 0.742; p < 0.001) between the permeation rate and thickness and volume fraction. With the inclusion of volume fraction in all regression models, the microstructure of the polymer played a critical role in chemical permeation, which requires further investigation. Based on these results, selection based on the availability of chemical permeation data for the product should always be preferred, especially when skin protection is critical. When chemical resistance ratings are based on general performance data, additional factors such as thickness and area density should be taken into consideration. In general, increases in thickness and area density are associated with increases in breakthrough time and decreases in the steady-state permeation rate. However, evidence in the literature and this study support the need for inclusion of additional factors associated with the microstructure of the polymer.

中文翻译：

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暴露在不同极性的挥发性有机化合物中的类似一次性丁腈手套的化学渗透性第2部分。预测的聚合物性能。

一项后续研究评估了10种一次性丁腈手套产品的化学和物理参数，以及观察到的化学渗透性能的变异性。目的是确定哪些聚合物性能可以解释或预测观察到的突破时间和稳态渗透率的广泛变化。评价的物理和机械性能为厚度，面积密度，体积分数和模量50-100％。评价的化学组成性质是相对的丙烯腈含量，相对的羧化含量，油性增塑剂，无机填料和有机聚合物含量。相关分析和多元回归分析相结合，以评估这些参数的预测性质。对于逐步分析，前向选择和后向消除方法用于确定最佳回归拟合。厚度和面积密度都与穿透时间密切相关。随着体积分数的增加，这些因素占突破时间变化的约88-89％。稳态渗透率的相关结果在很大程度上尚无定论，仅用一种溶剂即可观察到与厚度的适度相关。但是，回归分析显示渗透率与厚度和体积分数之间存在中等至强的关联（R2 = 0.742； p <0.001）。在所有回归模型中都包含体积分数后，聚合物的微观结构在化学渗透中起着关键作用，这需要进一步研究。根据这些结果，应始终优先选择基于产品化学渗透性数据的可用性，尤其是在皮肤保护至关重要的情况下。当化学抗性等级基于一般性能数据时，应考虑其他因素，例如厚度和面积密度。通常，厚度和面积密度的增加与穿透时间的增加和稳态渗透率的降低有关。然而，文献和本研究的证据支持需要包括与聚合物的微观结构相关的其他因素。应该考虑其他因素，例如厚度和面积密度。通常，厚度和面积密度的增加与穿透时间的增加和稳态渗透率的降低有关。然而，文献和本研究的证据支持需要包括与聚合物的微观结构相关的其他因素。应该考虑其他因素，例如厚度和面积密度。通常，厚度和面积密度的增加与穿透时间的增加和稳态渗透率的降低有关。然而，文献和本研究的证据支持需要包括与聚合物的微观结构相关的其他因素。